The Role of MIF-173GC Gene Polymorphism in the Susceptibility of Autoimmune Diseases
المؤلفون المشاركون
Xue, Haibo
Ma, Lei
Du, Xiangrong
Li, Ruixia
Song, Shoujun
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Some certain genetic polymorphisms have been considered to implicate in the pathogenesis and progression of autoimmune diseases and may predispose to an early stage of general autoimmune susceptibility.
Recent studies have been conducted to investigate the association between macrophage migration inhibitory factor- (MIF-) 173G/C gene polymorphism and autoimmune diseases; however, the results were not exactly identical.
In the present study, a systematic review and meta-analysis of case-control studies was performed to estimate the relationship.
A comprehensive search of PubMed, Ebsco, EMbase, WanFang databases and CNKI was done.
Odds ratio (ORs) and corresponding 95% confidence intervals (CIs) were combined to pool the effect size.
The publication bias was examined by Begg’s funnel plots and Egger’s test.
RevMan 5.3 and STATA 12.0 software were used for statistical processing.
23 papers were included, and the results revealed that MIF-173G/C was significantly associated with an increased risk of autoimmune diseases in five genetic models (recessive genetic model: OR=1.95, 95% CI: 1.52-2.50; dominant genetic model: OR=1.35, 95% CI: 1.24-1.46; allele model: OR=1.32, 95% CI: 1.23-1.41; homozygote model: OR=1.92, 95% CI: 1.57-2.35; heterozygote model: OR=4.92, 95% CI: 4.03-6.02), whether in Asia, Europe, or North America.
Furthermore, subgroup analysis showed an increasing risk in rheumatoid arthritis (RA), ulcerative colitis (UC), Crohn’s disease (CD), atopic dermatitis (AD), Henoch-Schonlein purpura (HSP), and Henoch-Schonlein purpura nephritis (HSPN), but it was not related to the susceptibility of autoimmune hepatitis (AIH).
Therefore, it could be considered that MIF-173G/C polymorphism could increase the susceptibility of autoimmune diseases, while there may be the discrepancy of disease entity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Du, Xiangrong& Li, Ruixia& Song, Shoujun& Ma, Lei& Xue, Haibo. 2020. The Role of MIF-173GC Gene Polymorphism in the Susceptibility of Autoimmune Diseases. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1191989
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Du, Xiangrong…[et al.]. The Role of MIF-173GC Gene Polymorphism in the Susceptibility of Autoimmune Diseases. Mediators of Inflammation No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1191989
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Du, Xiangrong& Li, Ruixia& Song, Shoujun& Ma, Lei& Xue, Haibo. The Role of MIF-173GC Gene Polymorphism in the Susceptibility of Autoimmune Diseases. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1191989
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191989
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر