The Plasma Soluble Urokinase Plasminogen Activator Receptor Is Related to Disease Activity of Patients with ANCA-Associated Vasculitis
المؤلفون المشاركون
Li, Yueqiang
Huang, Fei
Xu, Ranran
Cheng, Anying
Lv, Yongman
Liu, Qingquan
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
The soluble urokinase plasminogen activator receptor (suPAR) is associated with kidney diseases and is used as a prognostic factor of renal function progression.
The aim of this study was to explore whether circulating suPAR was associated with antineutrophil cytoplasmic autoantibody- (ANCA-) associated vasculitis (AAV) disease activity.
Methods.
We evaluated 90 AAV patients with follow-up data and 35 normal controls; their plasma suPAR and C-reactive protein (CRP) levels were measured by ELISA.
Associations between these levels, clinical parameters, and prognosis were analyzed.
Results.
Plasma suPAR levels in AAV patients were significantly higher than in healthy controls (5,920.08±3,447.17 vs.
1,441.97±835.04 pg/mL, P<0.001).
Furthermore, suPAR was significantly elevated in AAV patients in active stage compared to those in partial remissions (6,492.19±3,689.48 vs.
5,031.86±2,489.01 pg/mL, P=0.039).
Correlation analyses demonstrated that suPAR levels positively correlated with initial serum creatinine, BVAS, CRP, and procalcitonin concentration, and negatively correlated with eGFR and C3 circulating levels.
In a Kaplan-Meier survival analysis, patients with plasma suPAR levels >5683.3 pg/mL showed poorer survival than patients with lower levels (log-rank, P=0.001).
Besides, multivariate analyses confirmed that plasma suPAR levels were an independent adverse prognostic factor for a composite outcome of end-stage renal disease (ESRD) or death, after adjusting for age and gender (HR 1.05, 95% CI=1.01−1.11, P=0.043).
Receiver operating characteristic curves showed a suPAR cutoff value >6662.2 pg/mL for composite outcome with 68% sensitivity and 88% specificity, with an AUC=0.82, (95% CI=0.68−0.96, P<0.001).
Conclusion.
Circulating suPAR levels might be a marker of activity correlated with disease activity in AAV patients, and, to some extent, could be a factor of poor prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Fei& Li, Yueqiang& Xu, Ranran& Cheng, Anying& Lv, Yongman& Liu, Qingquan. 2020. The Plasma Soluble Urokinase Plasminogen Activator Receptor Is Related to Disease Activity of Patients with ANCA-Associated Vasculitis. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1191995
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Fei…[et al.]. The Plasma Soluble Urokinase Plasminogen Activator Receptor Is Related to Disease Activity of Patients with ANCA-Associated Vasculitis. Mediators of Inflammation No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1191995
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Fei& Li, Yueqiang& Xu, Ranran& Cheng, Anying& Lv, Yongman& Liu, Qingquan. The Plasma Soluble Urokinase Plasminogen Activator Receptor Is Related to Disease Activity of Patients with ANCA-Associated Vasculitis. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1191995
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191995
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر