The Imbalance of FOXP3GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients
المؤلفون المشاركون
Chen, Tiantian
Hou, Xiaoxia
Ni, Yingmeng
Du, Wei
Han, Huize
Yu, Youchao
Shi, Guochao
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Treg cells play an important role in the pathogenic progress of asthma.
Objective.
To address the alterations of Treg cells in asthma.
Methods.
Proliferation-and function-associated markers of Treg cells along with the percentage of Treg cells producing some cytokine from asthmatics and healthy subjects were analyzed by flow cytometry.
Besides, the expressions of USP21 and PIM2 in Treg cells were measured by cell immunochemistry after Treg cells were sorted.
Results.
Treg cells from asthmatic patients showed lower proliferation activity and were more likely to be apoptotic.
These cells expressed lower levels of GITR, CTLA-4, Nrp-1, and IL-10 compared to those from the healthy control.
Th2-like Treg cells increased in asthmatic patients, while the percentage of IFN-r+ Treg cells was similar between two groups.
Moreover, the percentage of IL-4+ Treg cells is related to the asthma control.
Treg cells from asthmatic patients expressed more FOXP3 as well as GATA3; the expression level of GATA3 negatively correlated with FEV1%pred.
Increased expressions of USP21 and PIM2 in Treg cells from asthmatic patients were found.
Conclusion.
Treg cells decreased in asthmatic patients, with an impaired immunosupression function and a Th2-like phenotype, which may be due to overexpression of GATA3 and FOXP3, regulated by USP21 and PIM2, respectively.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Tiantian& Hou, Xiaoxia& Ni, Yingmeng& Du, Wei& Han, Huize& Yu, Youchao…[et al.]. 2018. The Imbalance of FOXP3GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192043
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Tiantian…[et al.]. The Imbalance of FOXP3GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192043
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Tiantian& Hou, Xiaoxia& Ni, Yingmeng& Du, Wei& Han, Huize& Yu, Youchao…[et al.]. The Imbalance of FOXP3GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192043
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192043
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر