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New Potential Weapons for Refractory Scleritis in the Era of Targeted Therapy
المؤلفون المشاركون
Cantarini, Luca
Tosi, Gian Marco
Sainz de la Maza, Maite
Lopalco, Giuseppe
Emmi, Giacomo
Fabiani, Claudia
Sota, Jurgen
Pelegrín, Laura
Vannozzi, Lorenzo
Guerriero, Silvana
Gelmi, Maria Chiara
Hernández-Rodríguez, José
Rigante, Donato
Iannone, Florenzo
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-17
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To assess the efficacy of biologic drugs, beyond tumor necrosis factor- (TNF-) α inhibitors, in the management of noninfectious refractory scleritis, either idiopathic or associated with systemic immune-mediated disorders.
Patients and Methods.
This is a retrospective study assessing the efficacy of several biologic agents (rituximab, anakinra, tocilizumab, and abatacept) and the small molecule tofacitinib in the treatment of scleritis through assessment of scleral inflammation and relapses, as well as treatment impact on best-corrected visual acuity (BCVA) and safety profile.
Results.
Fourteen patients (19 eyes) were enrolled in the study.
Scleritis inflammatory grading significantly improved from baseline to 3 months (p=0.002) and from baseline to the last follow-up visit (p=0.002).
Scleritis relapses significantly decreased between the 12 months preceding and following biologic therapy (p=0.007).
No differences regarding BCVA were observed (p=0.67).
Regarding adverse events, only one patient developed pneumonia and septic shock under rituximab treatment.
Conclusions.
Our results, though limited to a low number of patients, highlight the effectiveness of different biologic therapies in the treatment of noninfectious refractory scleritis, showing to control scleral inflammation and allowing a significant reduction in the number of relapses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fabiani, Claudia& Sota, Jurgen& Sainz de la Maza, Maite& Pelegrín, Laura& Emmi, Giacomo& Lopalco, Giuseppe…[et al.]. 2020. New Potential Weapons for Refractory Scleritis in the Era of Targeted Therapy. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1192062
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fabiani, Claudia…[et al.]. New Potential Weapons for Refractory Scleritis in the Era of Targeted Therapy. Mediators of Inflammation No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1192062
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fabiani, Claudia& Sota, Jurgen& Sainz de la Maza, Maite& Pelegrín, Laura& Emmi, Giacomo& Lopalco, Giuseppe…[et al.]. New Potential Weapons for Refractory Scleritis in the Era of Targeted Therapy. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1192062
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192062
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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