Plasma and Cellular Forms of Fibronectin as Prognostic Markers in Sepsis
المؤلفون المشاركون
Adamik, Barbara
Lemańska-Perek, Anna
Krzyżanowska-Gołąb, Dorota
Skalec, Tomasz
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
There is a pressing need for specific prognostic markers that could be used to monitor the severity of sepsis.
The aims of our study were to investigate changes in the expression of different molecular forms of fibronectin in sepsis and to assess their relationship to the clinical severity and mortality of patients.
Material and Methods.
Forms of fibronectin: plasma (pFN), cellular (EDA-FN), FN-fibrin complexes, and fibronectin fragments were analyzed in 71 sepsis patients (survivors and nonsurvivors) and in the control by ELISA and immunoblotting.
Results.
The baseline pFN concentration of patients with sepsis was significantly lower than in the control (133.0 mg/L vs.
231.2 mg/L) (P<0.001), and in nonsurvivors, it was lower than in survivors (106.0 mg/L vs.
152.8 mg/L) (P=0.004).
The baseline EDA-FN was significantly elevated in both sepsis groups (survivors: 6.7 mg/L; nonsurvivors: 9.4 mg/L) compared to the control (1.4 mg/L) (P<0.001).
It should be noted that among patients with more severe sepsis, the EDA-FN level was higher in nonsurvivors than in survivors.
Furthermore, molecular FN-fibrin complexes as well as FN fragments occurred much more frequently in nonsurvivors than in survivors.
Conclusion.
The study showed that in sepsis, changes in plasmatic and cellular form of fibronectin were associated with the severity of sepsis and may be useful predictors of outcome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lemańska-Perek, Anna& Krzyżanowska-Gołąb, Dorota& Skalec, Tomasz& Adamik, Barbara. 2020. Plasma and Cellular Forms of Fibronectin as Prognostic Markers in Sepsis. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1192072
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lemańska-Perek, Anna…[et al.]. Plasma and Cellular Forms of Fibronectin as Prognostic Markers in Sepsis. Mediators of Inflammation No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1192072
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lemańska-Perek, Anna& Krzyżanowska-Gołąb, Dorota& Skalec, Tomasz& Adamik, Barbara. Plasma and Cellular Forms of Fibronectin as Prognostic Markers in Sepsis. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1192072
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192072
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر