Role of Anti-MICA Antibodies in Graft Survival of Renal Transplant Recipients of India
المؤلفون المشاركون
Chowdhry, Mohit
Makroo, R. N.
Singh, Mandhata
Kumar, Manoj
Thakur, Yogita
Sharma, Vandana
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
The MIC (MHC class I chain-related) genes are a group of nonclassical MHC genes, located in the MHC class 1 region of chromosome 6.
The aim of the present study was to find the prevalence of MHC class 1 chain-related (MICA) alloantibodies in patients undergoing live-related donor renal transplantation and its role in short-term graft survival.
The role of blood transfusion in the formation of these antibodies was also studied.
Materials and Methods.
Pretransplant samples of patients undergoing renal allograft transplantation were tested for anti-MICA antibodies.
Association of various demographics, HLA-A + B + DRB1 mismatches, anti-HLA antibody screen, and anti-MICA antibodies was assessed using Pearson’s chi-square test.
Results.
Out of 646 serum samples, 94 (14.6%) were positive and 552 (85.4%) were negative for anti-MICA antibodies.
Patients with anti-MICA antibody had a graft survival 89.3% as compared to 94.7% in patients without anti-MICA antibody (P<0.05).
The hazard ratio for all patients was 3.0701 (P<0.05).
Out of the 340 patients with no HLA antibodies, the presence of anti-MICA antibodies without any HLA antibodies (n=43) was associated with poor outcome in the patients (hazard ratio of 2.768, P<0.05).
The presence of MICA antibodies with HLA antibodies did not decrease the graft survival (hazards ratio of 1.3750, P>0.05).
Conclusion.
Preformed MICA antibodies independently increase the risk of kidney rejection and therefore recommend that guidelines should be formed for mandatory testing of these antibodies prior to renal transplant.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chowdhry, Mohit& Makroo, R. N.& Singh, Mandhata& Kumar, Manoj& Thakur, Yogita& Sharma, Vandana. 2018. Role of Anti-MICA Antibodies in Graft Survival of Renal Transplant Recipients of India. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1192089
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chowdhry, Mohit…[et al.]. Role of Anti-MICA Antibodies in Graft Survival of Renal Transplant Recipients of India. Journal of Immunology Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1192089
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chowdhry, Mohit& Makroo, R. N.& Singh, Mandhata& Kumar, Manoj& Thakur, Yogita& Sharma, Vandana. Role of Anti-MICA Antibodies in Graft Survival of Renal Transplant Recipients of India. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1192089
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192089
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر