Serum YKL-40 Levels Are Associated with the Atherogenic Index of Plasma in Children
المؤلفون المشاركون
Jee, Hye Mi
Baek, Hey Sung
Kwon, Yoowon
Kim, Ju Hee
Ha, Eun Kyo
Han, Man Yong
Jeong, Su Jin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
YKL-40, also known as chitinase-3-like protein 1, is an inflammatory glycoprotein that is secreted by various cell types under acute, chronic, and subclinical inflammation conditions.
Elevated serum YKL-40 levels are reportedly independently related to diabetes mellitus, coronary artery disease, acute myocardial infarction, and cardiovascular mortality in adults.
Therefore, we aimed to investigate the relationship between serum YKL-40 levels, lipid abnormalities, and the atherogenic index of plasma (AIP) in children.
We enrolled 479 children aged 10–12 years (mean age: 11.52) in this general population-based, cross-sectional study.
All subjects completed questionnaires and were subjected to multifrequency bioelectrical impedance analysis (BIA) to measure their height, weight, and body mass index (BMI).
We collected serum samples from all participants to measure YKL-40, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels.
Mean serum YKL-40 levels were significantly higher in the low-HDL-C (p=0.017) and high-TG (p=0.010) groups but were not related to TC and LDL-C levels.
YKL-40 levels were also higher in the high AIP group (p=0.007).
After adjusting for age, gender, and BMI z-score, the associations between serum YKL-40 levels and TG levels (p=0.003), the TG-to-HDL-C ratio (p=0.019), and the AIP value (p=0.012) remained significant.
Based on these findings, we suggest that serum YKL-40 may be a useful initial screening tool or follow-up risk indicator for lipid abnormalities, atherosclerosis, and cardiovascular disease in children and adolescents with risk factors, regardless of obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kwon, Yoowon& Kim, Ju Hee& Ha, Eun Kyo& Jee, Hye Mi& Baek, Hey Sung& Han, Man Yong…[et al.]. 2020. Serum YKL-40 Levels Are Associated with the Atherogenic Index of Plasma in Children. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1192127
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kwon, Yoowon…[et al.]. Serum YKL-40 Levels Are Associated with the Atherogenic Index of Plasma in Children. Mediators of Inflammation No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1192127
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kwon, Yoowon& Kim, Ju Hee& Ha, Eun Kyo& Jee, Hye Mi& Baek, Hey Sung& Han, Man Yong…[et al.]. Serum YKL-40 Levels Are Associated with the Atherogenic Index of Plasma in Children. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1192127
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192127
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر