Correlation between Blood and CSF Compartment Cytokines and Chemokines in Subjects with Cryptococcal Meningitis
المؤلفون المشاركون
Okafor, Elizabeth C.
Hullsiek, Katherine H.
Williams, Darlisha A.
Scriven, James E.
Rhein, Joshua
Nabeta, Henry W.
Musubire, Abdu K.
Rajasingham, Radha
Muzoora, Conrad
Schutz, Charlotte
Meintjes, Graeme
Meya, David B.
Boulware, David R.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-29
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Though peripheral blood is a crucial sample to study immunology, it is unclear whether the immune environment in the peripheral vasculature correlates with that at the end-organ site of infection.
Using cryptococcal meningitis as a model, we investigated the correlation between serum and cerebrospinal fluid biomarkers over time.
Methods.
We analyzed the cerebrospinal fluid and serum of 160 subjects presenting with first episode cryptococcal meningitis for soluble cytokines and chemokines measured by Luminex assay.
Specimens were collected at meningitis diagnosis, 1-week, and 2-week post cryptococcal diagnosis.
We compared paired samples by Spearman’s correlation and the p value was set at <0.01.
Results.
Of the 21 analytes tested at baseline, there was no correlation detected between nearly all analytes.
A weak negative correlation was found between serum and cerebrospinal fluid levels of interferon-gamma (Rho=−0.214; p=.007) and interleukin-4 (Rho=−0.232; p=.003).
There was no correlation at 1-week post cryptococcal diagnosis.
However, at 2-week post cryptococcal diagnosis, there was a weak positive correlation of granulocyte-macrophage colony-stimulating factor levels (Rho=0.25; p=.007) in serum and cerebrospinal fluid.
No cytokine or chemokine showed consistent correlation overtime.
Conclusion.
Based on our analysis of 21 biomarkers, serum and cerebrospinal fluid immune responses do not correlate.
There appears to be a distinct immune environment in terms of soluble biomarkers in the vasculature versus end-organ site of infection.
While this is a model of HIV-related cryptococcal meningitis, we postulate that assuming the blood compartment is representative of the immune function at the end-organ site of infection may not be appropriate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Okafor, Elizabeth C.& Hullsiek, Katherine H.& Williams, Darlisha A.& Scriven, James E.& Rhein, Joshua& Nabeta, Henry W.…[et al.]. 2020. Correlation between Blood and CSF Compartment Cytokines and Chemokines in Subjects with Cryptococcal Meningitis. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1192143
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Okafor, Elizabeth C.…[et al.]. Correlation between Blood and CSF Compartment Cytokines and Chemokines in Subjects with Cryptococcal Meningitis. Mediators of Inflammation No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1192143
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Okafor, Elizabeth C.& Hullsiek, Katherine H.& Williams, Darlisha A.& Scriven, James E.& Rhein, Joshua& Nabeta, Henry W.…[et al.]. Correlation between Blood and CSF Compartment Cytokines and Chemokines in Subjects with Cryptococcal Meningitis. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1192143
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192143
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر