Cangfudaotan Decoction Alleviates Insulin Resistance and Improves Follicular Development in Rats with Polycystic Ovary Syndrome via IGF-1-PI3KAkt-BaxBcl-2 Pathway
المؤلفون المشاركون
Wang, Chenye
Ding, Caifei
Hua, Zhoujia
Chen, Chunyue
Yu, Jia
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-24
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder prevalent in females of reproductive age; insulin resistance (IR) is the major pathogenic driver.
Pharmacology is a basic option for PCOS therapy; traditional Chinese medicine (TCM), as a significant part of complementary and alternative medicine, has a long history in the clinical management of PCOS.
Cangfudaotan decoction (CFD) has been used clinically for gynaecological diseases especially PCOS.
In this study, first, chemical components in CFD were clarified using UPLC-Q/TOF-MS analysis.
Then, an animal model of PCOS was established, granular cells were also isolated from the rats with PCOS, and CFD was administrated at different dosages in PCOS rats and granular cells, to investigate the therapeutic effect and mechanisms of CFD for PCOS treatment.
The result showed that CFD treatment is effective in PCOS rats and granulosa cells.
CFD was able to improve IR, restore the serum hormone levels, inhibit the inflammatory cytokines in PCOS rat, and alleviate ovary morphological injury and apoptosis in PCOS rats.
In granulosa cells of PCOS, the result showed that the cell viability was improved, and cell apoptosis was inhibited after CFD administration.
Further experiments suggested that CDF improves IR, follicular development, cell apoptosis, and inflammatory microenvironment, and this was associated to the regulation of IGF-1-PI3K/Akt-Bax/Bcl-2 pathway-mediated gene expression.
Given that CFD sufficiently suppresses insulin resistance and improves follicular development in this study, exploring these mechanisms might help to optimize the therapeutic treatment of CFD in PCOS patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Chenye& Ding, Caifei& Hua, Zhoujia& Chen, Chunyue& Yu, Jia. 2020. Cangfudaotan Decoction Alleviates Insulin Resistance and Improves Follicular Development in Rats with Polycystic Ovary Syndrome via IGF-1-PI3KAkt-BaxBcl-2 Pathway. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1192156
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Chenye…[et al.]. Cangfudaotan Decoction Alleviates Insulin Resistance and Improves Follicular Development in Rats with Polycystic Ovary Syndrome via IGF-1-PI3KAkt-BaxBcl-2 Pathway. Mediators of Inflammation No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1192156
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Chenye& Ding, Caifei& Hua, Zhoujia& Chen, Chunyue& Yu, Jia. Cangfudaotan Decoction Alleviates Insulin Resistance and Improves Follicular Development in Rats with Polycystic Ovary Syndrome via IGF-1-PI3KAkt-BaxBcl-2 Pathway. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1192156
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192156
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر