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Beneficial Effects of Rosmarinic Acid on IPEC-J2 Cells Exposed to the Combination of Deoxynivalenol and T-2 Toxin
المؤلفون المشاركون
Pomothy, Judit Mercédesz
Barna, Réka Fanni
Pászti, Erzsébet Anna
Babiczky, Ákos
Szóládi, Áron
Jerzsele, Ákos
Gere, Erzsébet Pásztiné
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Mycotoxin contamination in feedstuffs is a worldwide problem that causes serious health issues both in humans and animals, and it contributes to serious economic losses.
Deoxynivalenol (DON) and T-2 toxin (T-2) are major trichothecene mycotoxins and are known to challenge mainly intestinal barrier functions.
Polyphenolic rosmarinic acid (RA) appeared to have antioxidant and anti-inflammatory properties in vitro.
The aim of this study was to investigate protective effects of RA against DON and T-2 or combined mycotoxin-induced intestinal damage in nontumorigenic porcine cell line, IPEC-J2.
It was ascertained that simultaneous treatment of DON and T-2 (DT2: 1 μmol/L DON+5 nmol/L T−2) for 48 h and 72 h reduced transepithelial electrical resistance of cell monolayer, which was restored by 50 μmol/L RA application.
It was also found that DT2 for 48 h and 72 h could induce oxidative stress and elevate interleukin-6 (IL-6) and interleukin-8 (IL-8) levels significantly, which were alleviated by the administration of RA.
DT2 administration contributed to the redistribution of claudin-1; however, occludin membranous localization was not altered by combined mycotoxin treatment.
In conclusion, beneficial effect of RA was exerted on DT2-deteriorated cell monolayer integrity and on the perturbated redox status of IPEC-J2 cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pomothy, Judit Mercédesz& Barna, Réka Fanni& Pászti, Erzsébet Anna& Babiczky, Ákos& Szóládi, Áron& Jerzsele, Ákos…[et al.]. 2020. Beneficial Effects of Rosmarinic Acid on IPEC-J2 Cells Exposed to the Combination of Deoxynivalenol and T-2 Toxin. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1192170
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pomothy, Judit Mercédesz…[et al.]. Beneficial Effects of Rosmarinic Acid on IPEC-J2 Cells Exposed to the Combination of Deoxynivalenol and T-2 Toxin. Mediators of Inflammation No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1192170
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pomothy, Judit Mercédesz& Barna, Réka Fanni& Pászti, Erzsébet Anna& Babiczky, Ákos& Szóládi, Áron& Jerzsele, Ákos…[et al.]. Beneficial Effects of Rosmarinic Acid on IPEC-J2 Cells Exposed to the Combination of Deoxynivalenol and T-2 Toxin. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1192170
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192170
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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