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Recombinant Erythropoietin Provides Protection against Renal Fibrosis in Adenine-Induced Chronic Kidney Disease
المؤلفون المشاركون
Canales-Aguirre, Alejandro A.
Gutierrez-Mercado, Yanet
Márquez-Aguirre, Ana Laura
Vázquez-Méndez, Estefanía
Mendieta-Condado, Edgar
Gálvez-Gastélum, Francisco Javier
Esquivel-Solís, Hugo
Sánchez-Toscano, Yadira
Morales-Martínez, Claudia
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Chronic kidney disease (CKD) causes anemia by renal damage.
In CKD, the kidney is submitted to hypoxia, persistent inflammation, leading to fibrosis and permanent loss of renal function.
Human recombinant erythropoietin (rEPO) has been widely used to treat CKD-associated anemia and is known to possess organ-protective properties that are independent from its well-established hematopoietic effects.
Nonhematopoietic effects of EPO are mediated by an alternative receptor that is proposed to consist of a heterocomplex between the erythropoietin receptor (EPOR) and the beta common receptor (βcR).
The present study explored the effects of rEPO to prevent renal fibrosis in adenine-induced chronic kidney disease (Ad-CKD) and their association with the expression of the heterodimer EPOR/βcR.
Male Wistar rats were randomized to control group (CTL), adenine-fed rats (Ad-CKD), and Ad-CKD with treatment of rEPO (1050 IU/kg, once weekly for 4 weeks).
Ad-CKD rats exhibited anemia, uremia, decreased renal function, increased infiltration of inflammatory cells, tubular atrophy, and fibrosis.
rEPO treatment not only corrected anemia but reduced uremia and partially improved renal function as well.
In addition, we observed that rEPO diminishes tubular injury, prevents fibrosis deposition, and induces the EPOR/βcR heteroreceptor.
The findings may explain the extrahematopoietic effects of rEPO in CKD and provide new strategies for the treatment of renal fibrosis in CKD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vázquez-Méndez, Estefanía& Gutierrez-Mercado, Yanet& Mendieta-Condado, Edgar& Gálvez-Gastélum, Francisco Javier& Esquivel-Solís, Hugo& Sánchez-Toscano, Yadira…[et al.]. 2020. Recombinant Erythropoietin Provides Protection against Renal Fibrosis in Adenine-Induced Chronic Kidney Disease. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1192184
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vázquez-Méndez, Estefanía…[et al.]. Recombinant Erythropoietin Provides Protection against Renal Fibrosis in Adenine-Induced Chronic Kidney Disease. Mediators of Inflammation No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1192184
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vázquez-Méndez, Estefanía& Gutierrez-Mercado, Yanet& Mendieta-Condado, Edgar& Gálvez-Gastélum, Francisco Javier& Esquivel-Solís, Hugo& Sánchez-Toscano, Yadira…[et al.]. Recombinant Erythropoietin Provides Protection against Renal Fibrosis in Adenine-Induced Chronic Kidney Disease. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1192184
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192184
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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