Downregulation of Interleukin- (IL-) 17 through Enhanced Indoleamine 2,3-Dioxygenase (IDO) Induction by Curcumin: A Potential Mechanism of Tolerance towards Helicobacter pylori
المؤلفون المشاركون
Larussa, Tiziana
Imeneo, Maria
Suraci, Evelina
Gervasi, Serena
Liparoti, Rita
Marasco, Raffaella
Luzza, Francesco
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The anti-inflammatory and antimicrobial properties of curcumin suggest its use as an anti-Helicobacter pylori (H.
pylori) agent, but mechanisms underlying its helpful activity are still not clear.
Indoleamine 2,3-dioxygenase (IDO) promotes the effector T cell apoptosis by catalyzing the rate-limiting first step in tryptophan catabolism, and its high expression in H.
pylori-infected human gastric mucosa attenuates Th1 and Th17 immune response.
The aim of this study was to investigate the role of curcumin in modulating the expression of IL-17 and IDO in H.
pylori-infected human gastric mucosa.
In an organ culture chamber, gastric biopsies from 35 patients were treated with and without 200 μM curcumin.
In H.
pylori-infected patients (n=21), IL-17 was significantly lower, both in gastric biopsies (p=0.0003) and culture supernatant (p=0.0001) while IDO significantly increased (p<0.00001) in curcumin-treated sample compared with untreated samples.
In a subgroup of H.
pylori-infected patients (n=15), samples treated with curcumin in addition to IDO inhibitor 1-methyl-L-tryptophan (1-MT) showed a higher expression of IL-17 compared with untreated samples and curcumin-treated alone (p<0.00001).
Curcumin downregulates IL-17 production through the induction of IDO in H.
pylori-infected human gastric mucosa, suggesting its role in dampening H.
pylori-induced immune-mediated inflammatory changes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Larussa, Tiziana& Gervasi, Serena& Liparoti, Rita& Suraci, Evelina& Marasco, Raffaella& Imeneo, Maria…[et al.]. 2018. Downregulation of Interleukin- (IL-) 17 through Enhanced Indoleamine 2,3-Dioxygenase (IDO) Induction by Curcumin: A Potential Mechanism of Tolerance towards Helicobacter pylori. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1192186
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Larussa, Tiziana…[et al.]. Downregulation of Interleukin- (IL-) 17 through Enhanced Indoleamine 2,3-Dioxygenase (IDO) Induction by Curcumin: A Potential Mechanism of Tolerance towards Helicobacter pylori. Journal of Immunology Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1192186
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Larussa, Tiziana& Gervasi, Serena& Liparoti, Rita& Suraci, Evelina& Marasco, Raffaella& Imeneo, Maria…[et al.]. Downregulation of Interleukin- (IL-) 17 through Enhanced Indoleamine 2,3-Dioxygenase (IDO) Induction by Curcumin: A Potential Mechanism of Tolerance towards Helicobacter pylori. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1192186
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192186
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر