The Influence of Genetic Variations in the CD86 Gene on the Outcome after Allogeneic Hematopoietic Stem Cell Transplantation

المؤلفون المشاركون

Markiewicz, Miroslaw
Dzierzak-Mietla, Monika
Kyrcz-Krzemien, Slawomira
Karabon, L.
Pawlak-Adamska, E.
Frydecka, Irena
Chrobot, Karolina
Partyka, Anna
Koclega, Anna

المصدر

Journal of Immunology Research

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-02-07

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأحياء

الملخص EN

CD86 molecule is the ligand for both costimulatory (CD28) and coinhibitory (CTLA-4) molecules, and it regulates immune response after allogeneic hematopoietic stem cell transplantation (alloHSCT).

Therefore, we postulate that CD86 gene variations might influence the outcome after alloHSCT.

Altogether, 295 adult patients (pts) undergoing related (105 pts) and unrelated (190 pts) donor-matched HSCT were genotyped for the following CD86 gene polymorphisms: rs1129055, rs9831894, and rs2715267.

Moreover, the donors’ rs1129055 polymorphism was determined.

None of the investigated SNPs alone were associated with aGvHD and rate of relapse.

However, we showed that rs2715267 SNP influenced overall survival (OS) after alloHSCT.

The 24-month OS for the rs271526GG recipients was worse than that for the recipients possessing T allelle (TT or GT genotypes) (p=0.009).

Moreover, analysis of gene-gene interaction between CD86 and CTLA-4 showed that having both the A allele for CD86 rs1129055 and the CTLA-4 CT60GG genotype in recipients increased the risk of aGvHD about 3.5 times.

Interestingly, the donors’ rs1129055GG genotype and the recipients’ CT60GG genotype also increased the risk of aGvHD about 2.7-fold.

We postulate that recipients’ CD86 gene polymorphisms influence the overall survival after alloHSCT and, together with CTLA-4 polymorphisms, might be considered a risk factor for aGvHD.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Karabon, L.& Markiewicz, Miroslaw& Chrobot, Karolina& Dzierzak-Mietla, Monika& Pawlak-Adamska, E.& Partyka, Anna…[et al.]. 2018. The Influence of Genetic Variations in the CD86 Gene on the Outcome after Allogeneic Hematopoietic Stem Cell Transplantation. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1192246

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Karabon, L.…[et al.]. The Influence of Genetic Variations in the CD86 Gene on the Outcome after Allogeneic Hematopoietic Stem Cell Transplantation. Journal of Immunology Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1192246

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Karabon, L.& Markiewicz, Miroslaw& Chrobot, Karolina& Dzierzak-Mietla, Monika& Pawlak-Adamska, E.& Partyka, Anna…[et al.]. The Influence of Genetic Variations in the CD86 Gene on the Outcome after Allogeneic Hematopoietic Stem Cell Transplantation. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1192246

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1192246