Resistin Is Increased in Periodontal Cells and Tissues: In Vitro and In Vivo Studies
المؤلفون المشاركون
de Molon, Rafael Scaf
Deschner, James
Cirelli, Joni Augusto
Damanaki, Anna
Memmert, S.
Spolidorio, Luis C.
Jäger, Andreas
Nokhbehsaim, Marjan
Eick, Sigrun
Keser, Sema
Nogueira, Andressa Vilas Boas
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Resistin, a proinflammatory adipokine, is elevated in many inflammatory diseases.
However, little is known about its performance in periodontitis.
The present study is aimed at evaluating resistin expression and synthesis in periodontal cells and tissues under inflammatory/microbial stress in addition to its effects on the periodontium.
In vivo, 24 male rats were randomly divided into two groups: control and ligature-induced periodontal disease.
After 6 and 12 days, animals were sacrificed to analyze gene expression of adipokines, bone loss, inflammation, and resistin synthesis.
In vitro, human periodontal ligament (PDL) fibroblasts were used to evaluate the expression of resistin after inflammatory stimuli.
In addition, PDL fibroblasts were exposed to resistin to evaluate its role on soft and hard tissue metabolism markers.
The periodontitis group demonstrated significant bone loss, an increase in the number of inflammatory cells and vascular structures, an increase in resistin expression and synthesis, and a decrease in the expression of adiponectin, leptin, and its functional receptor.
PDL fibroblasts showed a significant increase in resistin expression and synthesis in response to the inflammatory stimulus by IL-1β.
Resistin induced an increase in cytokine expression and a decrease in the regulation of some hard tissue and matrix formation genes in PDL fibroblasts.
These data indicate that resistin is produced by periodontal cells and tissues, and this effect is enhanced by inflammatory stimuli.
Moreover, resistin seems to interfere with soft and hard tissue metabolism during periodontitis by reducing markers related to matrix formation and bone tissue.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nogueira, Andressa Vilas Boas& Nokhbehsaim, Marjan& Keser, Sema& de Molon, Rafael Scaf& Spolidorio, Luis C.& Memmert, S.…[et al.]. 2020. Resistin Is Increased in Periodontal Cells and Tissues: In Vitro and In Vivo Studies. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1192259
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nogueira, Andressa Vilas Boas…[et al.]. Resistin Is Increased in Periodontal Cells and Tissues: In Vitro and In Vivo Studies. Mediators of Inflammation No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1192259
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nogueira, Andressa Vilas Boas& Nokhbehsaim, Marjan& Keser, Sema& de Molon, Rafael Scaf& Spolidorio, Luis C.& Memmert, S.…[et al.]. Resistin Is Increased in Periodontal Cells and Tissues: In Vitro and In Vivo Studies. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1192259
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192259
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر