Phytochemical, Antioxidant and Mitochondrial Permeability Transition Studies on Fruit-Skin Ethanol Extract of Annona muricata
المؤلفون المشاركون
Chinedu, Shalom Nwodo
Iyanda-Joel, Wisdom O.
Ajetunmobi, Olusayo B.
Iweala, Emeka E. J.
Adegbite, Oluwatobi S.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Uncontrolled cell proliferation hallmarks cancer and most cancer cells have developed multiple resistance to the drugs employed for their treatment.
The study examined the phytochemical and antioxidant properties of the fruit-skin ethanol extract of Annona muricata Linn.
(ESA) and its effect on rat liver mitochondrial membrane permeability transition (MMPT).
Qualitative phytochemical study and antioxidant assays were carried out following established protocols while the opening of the MMPT pore in the presence of varying concentrations of the extract was assayed spectrophotometrically under succinate-energized conditions.
Calcium chloride (CaCl2) and spermine were used to trigger and inhibit pore opening respectively.
Cytochrome c release was assayed for using ELISA kit.
Terpenoids, steroids, phenols among other phytochemicals were found present in ESA and the extract showed very low antioxidant properties at the tested concentrations based on the diphenyl-1-picryhydrazyl (DPPH) radical scavenging activity assay.
Lipid peroxidation was induced in a concentration-dependent manner on both the cytosolic and mitochondrial hepatocyte fractions in vitro.
In the absence of CaCl2 0.84 mg/mL concentration of ESA induced MMPT pore opening by 129% while the extracts showed no inhibitory activity in its presence.
The induction fold corresponded with the concentrations of cytochrome c released.
The fruit-skin ethanol extract of Annona muricata at certain concentrations may possibly contain bioactive compounds that induce apoptosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Iyanda-Joel, Wisdom O.& Ajetunmobi, Olusayo B.& Chinedu, Shalom Nwodo& Iweala, Emeka E. J.& Adegbite, Oluwatobi S.. 2019. Phytochemical, Antioxidant and Mitochondrial Permeability Transition Studies on Fruit-Skin Ethanol Extract of Annona muricata. Journal of Toxicology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1192283
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Iyanda-Joel, Wisdom O.…[et al.]. Phytochemical, Antioxidant and Mitochondrial Permeability Transition Studies on Fruit-Skin Ethanol Extract of Annona muricata. Journal of Toxicology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1192283
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Iyanda-Joel, Wisdom O.& Ajetunmobi, Olusayo B.& Chinedu, Shalom Nwodo& Iweala, Emeka E. J.& Adegbite, Oluwatobi S.. Phytochemical, Antioxidant and Mitochondrial Permeability Transition Studies on Fruit-Skin Ethanol Extract of Annona muricata. Journal of Toxicology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1192283
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192283
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر