Evaluation of Soluble CD48 Levels in Patients with Allergic and Nonallergic Asthma in Relation to Markers of Type 2 and Non-Type 2 Immunity: An Observational Study
المؤلفون المشاركون
Breuer, Oded
Gangwar, Roopesh Singh
Seaf, Mansour
Barhoum, Ahlam
Kerem, Eitan
Levi-Schaffer, Francesca
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
CD48 is a costimulatory receptor associated with human asthma.
We aimed to assess the significance of the soluble form of CD48 (sCD48) in allergic and nonallergic asthma.
Volunteer patients completed an asthma and allergy questionnaire, spirometry, methacholine challenge test, a common allergen skin prick test, and a complete blood count.
sCD48, IgE, IL5, IL17A, IL33, and IFNγ were quantitated in serum by ELISA.
Asthma was defined as positive methacholine challenge test or a 15% increase in FEV1 post bronchodilator in symptomatic individuals.
Allergy was defined as positive skin test or IgE levels > 200 IU/l in symptomatic individuals.
137 individuals participated in the study: 82 (60%) were diagnosed with asthma of which 53 (64%) was allergic asthma.
sCD48 levels were significantly elevated in patients with nonallergic asthma compared to control and to the allergic asthma cohort (median (IQR) pg/ml, 1487 (1338–1758) vs.
1308 (1070–1581), p<0.01, and 1336 (1129–1591), p=0.02, respectively).
IL17A, IL33, and IFNγ levels were significantly elevated in allergic and nonallergic asthmatics when compared to control.
No correlation was found between sCD48 level and other disease markers.
sCD48 is elevated in nonallergic asthma.
Additional studies are required for understanding the role of sCD48 in airway disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Breuer, Oded& Gangwar, Roopesh Singh& Seaf, Mansour& Barhoum, Ahlam& Kerem, Eitan& Levi-Schaffer, Francesca. 2018. Evaluation of Soluble CD48 Levels in Patients with Allergic and Nonallergic Asthma in Relation to Markers of Type 2 and Non-Type 2 Immunity: An Observational Study. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1192288
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Breuer, Oded…[et al.]. Evaluation of Soluble CD48 Levels in Patients with Allergic and Nonallergic Asthma in Relation to Markers of Type 2 and Non-Type 2 Immunity: An Observational Study. Journal of Immunology Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1192288
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Breuer, Oded& Gangwar, Roopesh Singh& Seaf, Mansour& Barhoum, Ahlam& Kerem, Eitan& Levi-Schaffer, Francesca. Evaluation of Soluble CD48 Levels in Patients with Allergic and Nonallergic Asthma in Relation to Markers of Type 2 and Non-Type 2 Immunity: An Observational Study. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1192288
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192288
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر