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Phytochemical Screening and Toxicological Study of Aristolochia baetica Linn Roots: Histopathological and Biochemical Evidence
المؤلفون المشاركون
Benbacer, Laila
Bourhia, Mohammed
Khlil, Naima
Ait Haj Said, Amal
El Gueddari, Fatiha
Naamane, Abderrahim
Chaanoun, Ayoub
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aristolochia baetica (A.
baetica) is a wild species of Aristolochiaceae family; its roots are used by Moroccan people against cancer for many years ago.
The objective of the study was to investigate the phytochemical screening, acute and subacute toxicity of A.
baetica roots growing in the north of Morocco.
Qualitative and quantitative analyses of A.
baetica roots were performed using standard methods; the acute toxicity of the root extract of the studied plant was assessed in mice by gavage of single doses of 1, 2, and 4 g/kg body weight for 14 days; by the time the subacute toxicity was done using repeated doses 1, 1.5, and 2 g/kg/day for 28 days.
Histological changes and biochemical parameters as markers of kidney and liver function were evaluated.
The results of phytochemical screening showed the presence of polyphenols, tannins, alkaloids, flavonoids, saponins, and the absence of anthraquinones, sterols, and terpenes.
The results of acute toxicity showed the absence of mortality and signs of toxicity in groups treated with 1 and 2 g/kg; however, the clinical signs of toxicity were important and the rate of mortality was estimated at 16 % in the group treated with 4 g/kg.
The results of subacute toxicity showed several changes of serum parameters registered in groups treated with 1.5 and 2 g/kg/day, respectively.
The results showed also the absence of histological injuries in groups treated with 1 and 1.5 g/kg/day; meanwhile, the histological alterations were remarkable in treated group with the highest dose administered of 2 g/kg/day.
The outcome of this work showed that the roots’ extract of the studied plant was toxic in mice with repeated doses, but no toxic effect was observed with a single dose under 4g/kg.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bourhia, Mohammed& Ait Haj Said, Amal& Chaanoun, Ayoub& El Gueddari, Fatiha& Naamane, Abderrahim& Benbacer, Laila…[et al.]. 2019. Phytochemical Screening and Toxicological Study of Aristolochia baetica Linn Roots: Histopathological and Biochemical Evidence. Journal of Toxicology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1192291
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bourhia, Mohammed…[et al.]. Phytochemical Screening and Toxicological Study of Aristolochia baetica Linn Roots: Histopathological and Biochemical Evidence. Journal of Toxicology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1192291
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bourhia, Mohammed& Ait Haj Said, Amal& Chaanoun, Ayoub& El Gueddari, Fatiha& Naamane, Abderrahim& Benbacer, Laila…[et al.]. Phytochemical Screening and Toxicological Study of Aristolochia baetica Linn Roots: Histopathological and Biochemical Evidence. Journal of Toxicology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1192291
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192291
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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