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Gene Expression Profiling in Behcet’s Disease Indicates an Autoimmune Component in the Pathogenesis of the Disease and Opens New Avenues for Targeted Therapy
المؤلفون المشاركون
Lunardi, C.
Antonio, Puccetti
Giuseppe, Argentino
Patuzzo, Giuseppe
Pelosi, Andrea
Fiore, Piera Filomena
Moretta, Francesca
Dolcino, Marzia
Tinazzi, E.
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-24
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Behçet disease (BD) is a chronic inflammatory multisystem disease characterized by oral and genital ulcers, uveitis, and skin lesions.
Disease etiopathogenesis is still unclear.
We aim to elucidate some aspects of BD pathogenesis and to identify specific gene signatures in peripheral blood cells (PBCs) of patients with active disease using novel gene expression and network analysis.
179 genes were modulated in 10 PBCs of BD patients when compared to 10 healthy donors.
Among differentially expressed genes the top enriched gene function was immune response, characterized by upregulation of Th17-related genes and type I interferon- (IFN-) inducible genes.
Th17 polarization was confirmed by FACS analysis.
The transcriptome identified gene classes (vascular damage, blood coagulation, and inflammation) involved in the pathogenesis of the typical features of BD.
Following network analysis, the resulting interactome showed 5 highly connected regions (clusters) enriched in T and B cell activation pathways and 2 clusters enriched in type I IFN, JAK/STAT, and TLR signaling pathways, all implicated in autoimmune diseases.
We report here the first combined analysis of the transcriptome and interactome in PBCs of BD patients in the active stage of disease.
This approach generates useful insights in disease pathogenesis and suggests an autoimmune component in the origin of BD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Antonio, Puccetti& Fiore, Piera Filomena& Pelosi, Andrea& Tinazzi, E.& Patuzzo, Giuseppe& Giuseppe, Argentino…[et al.]. 2018. Gene Expression Profiling in Behcet’s Disease Indicates an Autoimmune Component in the Pathogenesis of the Disease and Opens New Avenues for Targeted Therapy. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1192292
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Antonio, Puccetti…[et al.]. Gene Expression Profiling in Behcet’s Disease Indicates an Autoimmune Component in the Pathogenesis of the Disease and Opens New Avenues for Targeted Therapy. Journal of Immunology Research No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1192292
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Antonio, Puccetti& Fiore, Piera Filomena& Pelosi, Andrea& Tinazzi, E.& Patuzzo, Giuseppe& Giuseppe, Argentino…[et al.]. Gene Expression Profiling in Behcet’s Disease Indicates an Autoimmune Component in the Pathogenesis of the Disease and Opens New Avenues for Targeted Therapy. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1192292
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192292
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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