Resistance Modulation Action, Time-Kill Kinetics Assay, and Inhibition of Biofilm Formation Effects of Plumbagin from Plumbago zeylanica Linn
المؤلفون المشاركون
Jibira, Yakubu
Adusei, Emmanuel B. A.
Adosraku, Reimmel K.
Oppong-Kyekyeku, James
Amengor, Cedric D. K.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Antimicrobial resistance (AMR) is a threat to the prevention and treatment of the increasing range of infectious diseases.
There is therefore the need for renewed efforts into antimicrobial discovery and development to combat the menace.
The antimicrobial activity of plumbagin isolated from roots of Plumbago zeylanica against selected organisms was evaluated for resistance modulation antimicrobial assay, time-kill kinetics assay, and inhibition of biofilm formation.
The minimum inhibitory concentrations (MICs) of plumbagin and standard drugs were determined via the broth microdilution method to be 0.5 to 8 μg/mL and 0.25–128 μg/mL, respectively.
In the resistance modulation study, MICs of the standard drugs were redetermined in the presence of subinhibitory concentration of plumbagin (4 μg/mL), and plumbagin was found to either potentiate or reduce the activities of these standard drugs with the highest potentiation recorded up to 12-folds for ketoconazole against Candida albicans.
Plumbagin was found to be bacteriostatic and fungistatic from the time-kill kinetics study.
Plumbagin demonstrated strong inhibition of biofilm formation activity at concentrations of 128, 64, and 32 μg/mL against the test microorganisms compared with ciprofloxacin.
Plumbagin has been proved through this study to be a suitable lead compound in antimicrobial resistance drug development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Adusei, Emmanuel B. A.& Adosraku, Reimmel K.& Oppong-Kyekyeku, James& Amengor, Cedric D. K.& Jibira, Yakubu. 2019. Resistance Modulation Action, Time-Kill Kinetics Assay, and Inhibition of Biofilm Formation Effects of Plumbagin from Plumbago zeylanica Linn. Journal of Tropical Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1192304
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Adusei, Emmanuel B. A.…[et al.]. Resistance Modulation Action, Time-Kill Kinetics Assay, and Inhibition of Biofilm Formation Effects of Plumbagin from Plumbago zeylanica Linn. Journal of Tropical Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1192304
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Adusei, Emmanuel B. A.& Adosraku, Reimmel K.& Oppong-Kyekyeku, James& Amengor, Cedric D. K.& Jibira, Yakubu. Resistance Modulation Action, Time-Kill Kinetics Assay, and Inhibition of Biofilm Formation Effects of Plumbagin from Plumbago zeylanica Linn. Journal of Tropical Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1192304
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192304
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر