Surfactant Protein D Is Altered in Experimental Malaria-Associated Acute Lung InjuryAcute Respiratory Distress Syndrome
المؤلفون المشاركون
Viriyavejakul, Parnpen
Punsawad, Chuchard
Techarang, Tachpon
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Surfactant protein D (SP-D) is in the collectin family of C-type lectins and plays an important role in the regulation of inflammation and the innate immune defense against pathogens.
This protein has been proposed as a biomarker for acute lung injury.
However, the expression of SP-D in the lung and the circulating levels of SP-D during malaria infection have received limited attention.
Therefore, the aim of this study was to determine the location and expression of the SP-D protein in lung tissue and to measure the plasma level of SP-D in experimental malaria-associated acute lung injury/acute respiratory distress syndrome (ALI/ARDS).
Malaria-infected mice induced by Plasmodium berghei ANKA were classified into two groups, namely, the ALI/ARDS and non-ALI/ARDS groups, according to lung histopathology.
The lungs of uninfected mice were used as a control group.
The location and expression of SP-D in the lung tissues were investigated by immunohistochemical staining and Western blot analysis.
In addition, the level of SP-D in plasma and lung homogenate was measured by an enzyme-linked immunosorbent assay.
Immunohistochemical staining of SP-D was significantly increased in the lung tissues of the malaria-infected mice in the ALI/ARDS group compared with that in the malaria-infected mice in the non-ALI/ARDS group and the mice in the control group (p < 0.05).
The levels of SP-D in the plasma and lung homogenate were significantly increased in the malaria-infected mice in the ALI/ARDS group compared with those in the malaria-infected mice in the non-ALI/ARDS group and the mice in the control group (p < 0.05).
There was a significant positive correlation between SP-D in the plasma and SP-D in the lung homogenate (rs = 0.900, p = 0.037).
In conclusion, this study demonstrated increased expression levels of SP-D in the lung tissue and high levels of plasma SP-D in the malaria-infected mice with ALI/ARDS compared with those in the mice in the other groups.
The current study supports that the elevation of the plasma SP-D level may provide useful biological confirmation of the diagnosis of ALI/ARDS during malaria infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Punsawad, Chuchard& Viriyavejakul, Parnpen& Techarang, Tachpon. 2019. Surfactant Protein D Is Altered in Experimental Malaria-Associated Acute Lung InjuryAcute Respiratory Distress Syndrome. Journal of Tropical Medicine،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1192398
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Punsawad, Chuchard…[et al.]. Surfactant Protein D Is Altered in Experimental Malaria-Associated Acute Lung InjuryAcute Respiratory Distress Syndrome. Journal of Tropical Medicine No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1192398
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Punsawad, Chuchard& Viriyavejakul, Parnpen& Techarang, Tachpon. Surfactant Protein D Is Altered in Experimental Malaria-Associated Acute Lung InjuryAcute Respiratory Distress Syndrome. Journal of Tropical Medicine. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1192398
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192398
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر