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Surfactant Protein D Is Altered in Experimental Malaria-Associated Acute Lung InjuryAcute Respiratory Distress Syndrome
المؤلفون المشاركون
Viriyavejakul, Parnpen
Punsawad, Chuchard
Techarang, Tachpon
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Surfactant protein D (SP-D) is in the collectin family of C-type lectins and plays an important role in the regulation of inflammation and the innate immune defense against pathogens.
This protein has been proposed as a biomarker for acute lung injury.
However, the expression of SP-D in the lung and the circulating levels of SP-D during malaria infection have received limited attention.
Therefore, the aim of this study was to determine the location and expression of the SP-D protein in lung tissue and to measure the plasma level of SP-D in experimental malaria-associated acute lung injury/acute respiratory distress syndrome (ALI/ARDS).
Malaria-infected mice induced by Plasmodium berghei ANKA were classified into two groups, namely, the ALI/ARDS and non-ALI/ARDS groups, according to lung histopathology.
The lungs of uninfected mice were used as a control group.
The location and expression of SP-D in the lung tissues were investigated by immunohistochemical staining and Western blot analysis.
In addition, the level of SP-D in plasma and lung homogenate was measured by an enzyme-linked immunosorbent assay.
Immunohistochemical staining of SP-D was significantly increased in the lung tissues of the malaria-infected mice in the ALI/ARDS group compared with that in the malaria-infected mice in the non-ALI/ARDS group and the mice in the control group (p < 0.05).
The levels of SP-D in the plasma and lung homogenate were significantly increased in the malaria-infected mice in the ALI/ARDS group compared with those in the malaria-infected mice in the non-ALI/ARDS group and the mice in the control group (p < 0.05).
There was a significant positive correlation between SP-D in the plasma and SP-D in the lung homogenate (rs = 0.900, p = 0.037).
In conclusion, this study demonstrated increased expression levels of SP-D in the lung tissue and high levels of plasma SP-D in the malaria-infected mice with ALI/ARDS compared with those in the mice in the other groups.
The current study supports that the elevation of the plasma SP-D level may provide useful biological confirmation of the diagnosis of ALI/ARDS during malaria infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Punsawad, Chuchard& Viriyavejakul, Parnpen& Techarang, Tachpon. 2019. Surfactant Protein D Is Altered in Experimental Malaria-Associated Acute Lung InjuryAcute Respiratory Distress Syndrome. Journal of Tropical Medicine،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1192398
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Punsawad, Chuchard…[et al.]. Surfactant Protein D Is Altered in Experimental Malaria-Associated Acute Lung InjuryAcute Respiratory Distress Syndrome. Journal of Tropical Medicine No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1192398
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Punsawad, Chuchard& Viriyavejakul, Parnpen& Techarang, Tachpon. Surfactant Protein D Is Altered in Experimental Malaria-Associated Acute Lung InjuryAcute Respiratory Distress Syndrome. Journal of Tropical Medicine. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1192398
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192398
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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