A Novel Inflammation-Based Prognostic Score: The FibrinogenAlbumin Ratio Predicts Prognoses of Patients after Curative Resection for Hepatocellular Carcinoma
المؤلفون المشاركون
Xu, Qiaodong
Yan, Yongcong
Gu, Songgang
Mao, Kai
Zhang, Jianlong
Huang, Pinbo
Zhou, Zhenyu
Chen, Zheng
Zheng, Shaodong
Liang, Jiahong
Lin, Zhihua
Wang, Jie
Yan, Jiang
Xiao, Zhiyu
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Inflammation is an important hallmark of cancer.
Fibrinogen and albumin are both vital factors in systemic inflammation.
This study investigated the prognostic value of the fibrinogen/albumin ratio in HCC patients who underwent curative resection.
Methods.
HCC patients (n=151) who underwent curative resection were evaluated retrospectively.
The optimal cutoff value for the fibrinogen/albumin ratio was selected by receiver operating characteristic (ROC) curve analysis.
Correlations between preoperative fibrinogen/albumin ratios and clinicopathologic characteristics were analyzed by χ2 test.
The area under the receiver operating characteristic curve (AUC) was calculated to compare the prognostic value of the fibrinogen/albumin ratio with other prognostic scores (neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and albumin-bilirubin (ALBI) score).
The overall survival (OS) and time to recurrence (TTR) were assessed by the log-rank test and the Cox proportional hazard regression model.
Results.
An optimal cutoff value of the preoperative fibrinogen/albumin ratio (0.062) was determined for 151 patients who underwent curative resection for HCC via a ROC curve analysis.
Fibrinogen/albumin ratio > 0.062 was significantly associated with microvascular invasion, an advanced BCLC stage, and ALBI grade.
Multivariate analyses revealed that fibrinogen/albumin ratio was an independent predictor for OS (P=0.003) and TTR (P=0.035).
The prognostic ability of fibrinogen/albumin ratio was comparable to other prognostic scores (NLR, PLR, and ALBI score) by AUC analysis.
Patients with a fibrinogen/albumin ratio > 0.062 had lower 1-, 3-, and 5-year OS rates (66.0%, 41.8%, and 28.2% versus 81.9%, 69.3%, and 56.1%, resp., P<0.001) and higher 1-, 3-, and 5-year recurrence rates (60.9%, 79.2%, and 90.5% versus 49.5%, 69.1%, and 77.1%, resp., P=0.008) compared with patients with fibrinogen/albumin ratio ≤ 0.062.
Conclusion.
The preoperative fibrinogen/albumin ratio is an effective prognostic factor for HCC patients who underwent curative resection.
An elevated fibrinogen/albumin ratio significantly correlates with poorer survival and a higher risk of recurrence in HCC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Qiaodong& Yan, Yongcong& Gu, Songgang& Mao, Kai& Zhang, Jianlong& Huang, Pinbo…[et al.]. 2018. A Novel Inflammation-Based Prognostic Score: The FibrinogenAlbumin Ratio Predicts Prognoses of Patients after Curative Resection for Hepatocellular Carcinoma. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1192422
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Qiaodong…[et al.]. A Novel Inflammation-Based Prognostic Score: The FibrinogenAlbumin Ratio Predicts Prognoses of Patients after Curative Resection for Hepatocellular Carcinoma. Journal of Immunology Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1192422
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Qiaodong& Yan, Yongcong& Gu, Songgang& Mao, Kai& Zhang, Jianlong& Huang, Pinbo…[et al.]. A Novel Inflammation-Based Prognostic Score: The FibrinogenAlbumin Ratio Predicts Prognoses of Patients after Curative Resection for Hepatocellular Carcinoma. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1192422
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192422
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر