A Prognostic Tool for Individualized Prediction of Graft Failure Risk within Ten Years after Kidney Transplantation
المؤلفون المشاركون
Stamenic, Danko
Rousseau, Annick
Essig, Marie
Gatault, Philippe
Buchler, Mathias
Filloux, Matthieu
Marquet, Pierre
Prémaud, Aurélie
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Identification of patients at risk of kidney graft loss relies on early individual prediction of graft failure.
Data from 616 kidney transplant recipients with a follow-up of at least one year were retrospectively studied.
A joint latent class model investigating the impact of serum creatinine (Scr) time-trajectories and onset of de novo donor-specific anti-HLA antibody (dnDSA) on graft survival was developed.
The capacity of the model to calculate individual predicted probabilities of graft failure over time was evaluated in 80 independent patients.
The model classified the patients in three latent classes with significantly different Scr time profiles and different graft survivals.
Donor age contributed to explaining latent class membership.
In addition to the SCr classes, the other variables retained in the survival model were proteinuria measured one-year after transplantation (HR=2.4, p=0.01), pretransplant non-donor-specific antibodies (HR=3.3, p<0.001), and dnDSA in patient who experienced acute rejection (HR=15.9, p=0.02).
In the validation dataset, individual predictions of graft failure risk provided good predictive performances (sensitivity, specificity, and overall accuracy of graft failure prediction at ten years were 77.7%, 95.8%, and 85%, resp.) for the 60 patients who had not developed dnDSA.
For patients with dnDSA individual risk of graft failure was not predicted with a so good performance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Stamenic, Danko& Rousseau, Annick& Essig, Marie& Gatault, Philippe& Buchler, Mathias& Filloux, Matthieu…[et al.]. 2019. A Prognostic Tool for Individualized Prediction of Graft Failure Risk within Ten Years after Kidney Transplantation. Journal of Transplantation،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1192456
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Stamenic, Danko…[et al.]. A Prognostic Tool for Individualized Prediction of Graft Failure Risk within Ten Years after Kidney Transplantation. Journal of Transplantation No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1192456
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Stamenic, Danko& Rousseau, Annick& Essig, Marie& Gatault, Philippe& Buchler, Mathias& Filloux, Matthieu…[et al.]. A Prognostic Tool for Individualized Prediction of Graft Failure Risk within Ten Years after Kidney Transplantation. Journal of Transplantation. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1192456
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192456
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر