HuoXueTongFu Formula Alleviates Intraperitoneal Adhesion by Regulating Macrophage Polarization and the SOCSJAK2STATPPAR-γ Signalling Pathway
المؤلفون المشاركون
Bian, Yaoyao
Yang, Lili
Zeng, Li
Zhao, Min
Chen, Yan-Qi
Wang, Ya-Jie
Ma, Yan-Ting
Pei, Yu-Qiong
Li, Wen-Lin
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-21
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Intraperitoneal adhesion is a common complication after abdominal surgery, which seriously affects the quality of life of patients.
HuoXueTongFu Formula (HXTF) plays an important role in the prevention and treatment of intraperitoneal adhesions.
However, the molecular-related mechanisms are still not fully known.
In this study, the model of Intrapetitoneal adhesion was established by cecum abrasion and treated with HXTF for one week.
RAW264.7 cells were given LPS, IFN-γ, IL-4, HXTF-medicated serum, and PPAR-γ agonist/antagonist, respectively.
Histopathology, flow cytometry, ELISA, real-time PCR, and Western blotting were used to further detect the related protein, M1/M2 polarization tendency, and PPAR-γ nuclear translocation.
The deposition of collagen fibres reduced in the local area of rats after the operation with HXTF treatment.
Similar to IL-4, HXTF induced a tendency for macrophages to polarize toward M2 and promoted peroxisome proliferator-activated receptor-gamma (PPAR-γ) nuclear translocation.
Furthermore, the use of HXTF and PPAR-γ agonists downregulated macrophage M1 polarization-related factors IL-1, IL-6, and TNF-alpha and upregulated M2 polarization-related factors IL-4, IL-10, and TGF-beta 1.
Meanwhile, the use of HXTF and PPAR-γ agonists downregulated the SOCS3/JAK2/STAT1 pathway and activated the SOCS1/STAT6/PPAR-γ pathway.
These results show that HXTF may reduce intraperitoneal adhesion by inducing macrophage M2 polarization and regulating the SOCS/JAK2/STAT/PPAR-γ pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Min& Bian, Yaoyao& Yang, Lili& Chen, Yan-Qi& Wang, Ya-Jie& Ma, Yan-Ting…[et al.]. 2019. HuoXueTongFu Formula Alleviates Intraperitoneal Adhesion by Regulating Macrophage Polarization and the SOCSJAK2STATPPAR-γ Signalling Pathway. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1192640
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Min…[et al.]. HuoXueTongFu Formula Alleviates Intraperitoneal Adhesion by Regulating Macrophage Polarization and the SOCSJAK2STATPPAR-γ Signalling Pathway. Mediators of Inflammation No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1192640
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Min& Bian, Yaoyao& Yang, Lili& Chen, Yan-Qi& Wang, Ya-Jie& Ma, Yan-Ting…[et al.]. HuoXueTongFu Formula Alleviates Intraperitoneal Adhesion by Regulating Macrophage Polarization and the SOCSJAK2STATPPAR-γ Signalling Pathway. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1192640
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192640
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر