Macrophage Migration Inhibitory Factor Promotes the Interaction between the Tumor, Macrophages, and T Cells to Regulate the Progression of Chemically Induced Colitis-Associated Colorectal Cancer
المؤلفون المشاركون
Juárez, Imelda
Juárez, Imelda
Pérez-Plasencia, Carlos
Chirino, Yolanda I.
Pacheco-Fernández, Thalia
Illescas, Oscar
Gutiérrez-Cirlos, Emma B.
Maldonado, Vilma
Ávila-Moreno, Federico
Reyes, José Luis
Hernández-Pando, Rogelio
Terrazas, Luis I.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-10
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Colitis-associated colorectal cancer (CRC) development has been shown to be related to chronically enhanced inflammation.
Macrophage migration inhibitory factor (MIF) is an inflammatory mediator that favors inflammatory cytokine production and has chemotactic properties for the recruitment of macrophages (Møs) and T cells.
Here, we investigated the role of MIF in the inflammatory response and recruitment of immune cells in a murine model of chemical carcinogenesis to establish the impact of MIF on CRC genesis and malignancy.
We used BALB/c MIF-knockout (MIF-/-) and wild-type (WT) mice to develop CRC by administering intraperitoneal (i.p.) azoxymethane and dextran sodium sulfate in drinking water.
Greater tumor burdens were observed in MIF-/- mice than in WT mice.
Tumors from MIF-/- mice were histologically identified to be more aggressive than tumors from WT mice.
The localization of MIF suggests that it is also involved in cell differentiation.
The relative gene expression of il-17, measured by real-time PCR, was higher in MIF-/- CRC mice, compared to the WT CRC and healthy MIF-/- mice.
Importantly, compared to the WT intestinal epithelium, lower percentages of tumor-associated Møs were found in the MIF-/- intestinal epithelium.
These results suggest that MIF plays a role in controlling the initial development of CRC by attracting Møs to the tumor, which is a condition that favors the initial antitumor responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pacheco-Fernández, Thalia& Juárez, Imelda& Illescas, Oscar& Terrazas, Luis I.& Hernández-Pando, Rogelio& Pérez-Plasencia, Carlos…[et al.]. 2019. Macrophage Migration Inhibitory Factor Promotes the Interaction between the Tumor, Macrophages, and T Cells to Regulate the Progression of Chemically Induced Colitis-Associated Colorectal Cancer. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1192670
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pacheco-Fernández, Thalia…[et al.]. Macrophage Migration Inhibitory Factor Promotes the Interaction between the Tumor, Macrophages, and T Cells to Regulate the Progression of Chemically Induced Colitis-Associated Colorectal Cancer. Mediators of Inflammation No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1192670
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pacheco-Fernández, Thalia& Juárez, Imelda& Illescas, Oscar& Terrazas, Luis I.& Hernández-Pando, Rogelio& Pérez-Plasencia, Carlos…[et al.]. Macrophage Migration Inhibitory Factor Promotes the Interaction between the Tumor, Macrophages, and T Cells to Regulate the Progression of Chemically Induced Colitis-Associated Colorectal Cancer. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1192670
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192670
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر