![](/images/graphics-bg.png)
Renal Evaluation in Common Variable Immunodeficiency
المؤلفون المشاركون
Capistrano, Giovany Gomes
Meneses, Gdayllon Cavalcante
de Oliveira Neves, Fernanda Macedo
de Almeida Leitão, Renata
Martins, Alice Maria Costa
Libório, Alexandre Braga
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-15
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
Common variable immunodeficiency (CVID) comprises a heterogeneous group of disorders characterized by impaired antibody production.
Kidney involvement in CVID is described in isolated and sporadic case reports.
The objective of this study was to study the renal function pattern in CVID patients through glomerular and tubular function tests.
Methods.
Study of 12 patients with CVID diagnosis and 12 healthy control individuals.
Glomerular filtration rate (GFR), fractional excretion of sodium (FENa+) and potassium (FEK+), urinary concentration, and acidification capacity were measured.
In addition, microalbuminuria and urinary monocyte chemoattractant protein-1 (MCP-1) were evaluated as markers of selectivity of the glomerular barrier and inflammation, respectively.
Results.
In relation to glomerular markers, all CVID patients had normal GFR (>90 mL/min/1.73 m2), and microalbuminuria and urinary MCP-1 levels were also similar to those of controls.
Interestingly, CVID patients had reduced urinary concentration capacity, as demonstrated by lower U/POsm ratio, when compared to controls.
Also, while all control subjects achieved a urinary pH less than 5.3, no CVID patients showed a decrease in urinary pH to such levels in response to acid loading with CaCl2, characterizing impaired urinary acidification capacity.
Conclusion.
Patients showed a trend towards an elevated prevalence of tubular dysfunction, mainly related to urinary acidification and concentration capacities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Capistrano, Giovany Gomes& Meneses, Gdayllon Cavalcante& de Oliveira Neves, Fernanda Macedo& de Almeida Leitão, Renata& Martins, Alice Maria Costa& Libório, Alexandre Braga. 2018. Renal Evaluation in Common Variable Immunodeficiency. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1192674
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Capistrano, Giovany Gomes…[et al.]. Renal Evaluation in Common Variable Immunodeficiency. Journal of Immunology Research No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1192674
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Capistrano, Giovany Gomes& Meneses, Gdayllon Cavalcante& de Oliveira Neves, Fernanda Macedo& de Almeida Leitão, Renata& Martins, Alice Maria Costa& Libório, Alexandre Braga. Renal Evaluation in Common Variable Immunodeficiency. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1192674
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192674
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)