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Angiotensin-(1-7) and Alamandine Promote Anti-inflammatory Response in Macrophages In Vitro and In Vivo
المؤلفون المشاركون
Souza dos Santos, Robson Augusto
Vago, Juliana Priscila
Sousa, Lirlândia Pires
de Carvalho Santuchi, Melissa
Dutra, Miriane Fernandes
Lima, Kátia Maciel
Galvão, Izabela
de Souza-Neto, Fernando Pedro
Morais e Silva, Mario
Oliveira, Aline Cristina
de Oliveira, Flávia Carvalho Bittencourt
Gonçalves, Ricardo
da Silva, Rafaela Fernandes
Teixeira, Mauro Martins
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-21
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The renin-angiotensin system (RAS) peptides play an important role in inflammation.
Resolution of inflammation contributes to restore tissue homeostasis, and it is characterized by neutrophil apoptosis and their subsequent removal by macrophages, which are remarkable plastic cells involved in the pathophysiology of diverse inflammatory diseases.
However, the effects of RAS peptides on different macrophage phenotypes are still emerging.
Here, we evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the most novel RAS peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-γ), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice.
Our results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-α, CCL2, and IL-1β transcript expression levels in LPS+IFN-γ-stimulated macrophages.
Therapeutic administration of these peptides in LPS-induced inflammation in mice decreased the number of neutrophils and M1 (F4/80lowGr1+CD11bmed) macrophage frequency without affecting the other investigated macrophage subsets.
Our data suggested that both Ang-(1-7) and alamandine, through their respective receptors Mas and MrgD, promote an anti-inflammatory reprogramming of M(LPS+IFN-γ)/M1 macrophages under inflammatory circumstances and potentiate the reprogramming induced by IL-4.
In conclusion, our work sheds light on the emerging proresolving properties of Ang-(1-7) and alamandine, opening new avenues for the treatment of inflammatory diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Carvalho Santuchi, Melissa& Dutra, Miriane Fernandes& Vago, Juliana Priscila& Lima, Kátia Maciel& Galvão, Izabela& de Souza-Neto, Fernando Pedro…[et al.]. 2019. Angiotensin-(1-7) and Alamandine Promote Anti-inflammatory Response in Macrophages In Vitro and In Vivo. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1192705
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Carvalho Santuchi, Melissa…[et al.]. Angiotensin-(1-7) and Alamandine Promote Anti-inflammatory Response in Macrophages In Vitro and In Vivo. Mediators of Inflammation No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1192705
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Carvalho Santuchi, Melissa& Dutra, Miriane Fernandes& Vago, Juliana Priscila& Lima, Kátia Maciel& Galvão, Izabela& de Souza-Neto, Fernando Pedro…[et al.]. Angiotensin-(1-7) and Alamandine Promote Anti-inflammatory Response in Macrophages In Vitro and In Vivo. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1192705
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192705
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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