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Association of Platelet Binding to Lymphocytes with B Cell Abnormalities and Clinical Manifestations in Systemic Lupus Erythematosus
المؤلفون المشاركون
Zamora, Carlos
Toniolo, Elide
Diaz-Torné, Cesar
Cantó, Elisabet
Magallares, Berta
Ortiz, Ma Angels
Perea, Lidia
Corominas, Hector
Vidal, Silvia
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Systemic lupus erythematosus (SLE) is an autoimmune disease associated with the polyclonal activation of B lymphocytes and the production of autoantibodies that cause immune complex-related inflammation.
Immunological factors derived from platelets modulate B cell function in SLE disease.
However, platelets do not only modify the immune system by soluble factors.
The binding of platelets to lymphocytes can modulate immune response.
Thus, we speculate that the binding of platelets to lymphocytes in SLE patients may play a role in abnormal B lymphocyte response and the pathogenesis of SLE.
We observed that levels of lymphocytes with bound platelets were higher in SLE patients than in healthy donors (HD).
In SLE patients, the percentage of B lymphocytes with bound platelets positively correlated with plasmatic levels of IgG, IgA, IL-10, and soluble CD40L and negatively correlated with IgM levels, though not in HD.
Preswitched memory B lymphocytes were the subpopulation with more bound platelets.
Lymphocytes with bound platelets from both HD and SLE patients had major levels of CD86 and BAFFR and a greater production of IL-10 than lymphocytes without bound platelets.
However, only B lymphocytes with bound platelets from SLE patients had increased levels of IgG and IgA on their surface.
SLE patients with a suggestive renal manifestation had the highest levels of B and T lymphocytes with bound platelets.
These results suggest that the binding of platelets to lymphocytes plays a role in SLE disease and that controlling this binding may be a promising therapeutic approach.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zamora, Carlos& Toniolo, Elide& Diaz-Torné, Cesar& Cantó, Elisabet& Magallares, Berta& Ortiz, Ma Angels…[et al.]. 2019. Association of Platelet Binding to Lymphocytes with B Cell Abnormalities and Clinical Manifestations in Systemic Lupus Erythematosus. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1192713
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zamora, Carlos…[et al.]. Association of Platelet Binding to Lymphocytes with B Cell Abnormalities and Clinical Manifestations in Systemic Lupus Erythematosus. Mediators of Inflammation No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1192713
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zamora, Carlos& Toniolo, Elide& Diaz-Torné, Cesar& Cantó, Elisabet& Magallares, Berta& Ortiz, Ma Angels…[et al.]. Association of Platelet Binding to Lymphocytes with B Cell Abnormalities and Clinical Manifestations in Systemic Lupus Erythematosus. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1192713
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192713
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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