IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome
المؤلفون المشاركون
Guo, Min
Yan, Rui
Yao, Hongmei
Duan, Liqin
Sun, Meng
Xue, Zheng
Jia, Yongping
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-01
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Atherosclerosis (AS) is recognized as a chronic inflammatory disease.
It is caused by the interaction between inflammatory cells such as macrophages, dendritic cells, and lipoproteins.
Evidence has revealed that macrophage pyroptosis in lesion contributes to the formation of the necrotic core and thinning of the fibrous cap, which plays crucial roles in the onset of acute coronary syndrome (ACS).
IFN regulatory factor 1 (IRF-1) is a pleiotropic transcription factor involved in various immune processes and cell death.
We propose that IRF-1 may be implicated in macrophage pyroptosis in the pathogenesis of AS and ACS.
Methods.
Patients with stable angina, unstable angina, acute myocardial infarction, and clinical presentation of chest pain were enrolled.
The expression of IRF-1 in human PBMC-derived macrophages was analyzed.
Then, overexpression and inhibition of IRF-1 was performed in macrophages from patients with ACS to explore the possible role and mechanism of IRF-1 involvement in macrophage pyroptosis.
Results.
The expression of IRF-1 in macrophages was upregulated in ACS patients.
The overexpression or inhibition of IRF-1 effectively modulated caspase-1 activation, as well as macrophage lysis, expression of gasdermin D-N (GSDMD-N), production of IL-1β and IL-18, and activation of NLRP3-ASC inflammasome, which were all inhibited by caspase-1 inhibitor.
Further experiments revealed that pyroptosis and the downstream inflammatory response in AS induced by IRF-1 is a process that is dependent on reactive oxygen species (ROS) generation.
Conclusion.
Our observations suggest that IRF-1 potently activates ox-LDL-induced macrophage pyroptosis and may play an important role in AS and ACS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Min& Yan, Rui& Yao, Hongmei& Duan, Liqin& Sun, Meng& Xue, Zheng…[et al.]. 2019. IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1192742
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Min…[et al.]. IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome. Mediators of Inflammation No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1192742
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Min& Yan, Rui& Yao, Hongmei& Duan, Liqin& Sun, Meng& Xue, Zheng…[et al.]. IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1192742
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192742
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر