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Hints for Genetic and Clinical Differentiation of Adult-Onset Monogenic Autoinflammatory Diseases
المؤلفون المشاركون
Vitale, Antonio
Cantarini, Luca
Renieri, Alessandra
Frediani, Bruno
Gelardi, Viviana
Gaggiano, Carla
Fabbiani, Alessandra
Capozio, Giovanna
Marzo, Chiara
Grosso, Salvatore
Rigante, Donato
Lucherini, Orso Maria
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-29، 29ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-31
دولة النشر
مصر
عدد الصفحات
29
التخصصات الرئيسية
الملخص EN
Monogenic autoinflammatory diseases (mAIDs) are inherited errors of innate immunity characterized by systemic inflammation recurring with variable frequency and involving the skin, serosal membranes, synovial membranes, joints, the gastrointestinal tube, and/or the central nervous system, with reactive amyloidosis as a potential severe long-term consequence.
Although individually uncommon, all mAIDs set up an emerging chapter of internal medicine: recent findings have modified our knowledge regarding mAID pathophysiology and clarified that protean inflammatory symptoms can be variably associated with periodic fevers, depicting multiple specific conditions which usually start in childhood, such as familial Mediterranean fever, tumor necrosis factor receptor-associated periodic syndrome, cryopyrin-associated periodic syndrome, and mevalonate kinase deficiency.
There are no evidence-based studies to establish which potential genotype analysis is the most appropriate in adult patients with clinical phenotypes suggestive of mAIDs.
This review discusses genetic and clinical hints for an ideal diagnostic approach to mAIDs in adult patients, as their early identification is essential to prompt effective treatment and improve quality of life, and also highlights the most recent developments in the diagnostic work-up for the most frequent hereditary periodic febrile syndromes worldwide.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gaggiano, Carla& Rigante, Donato& Vitale, Antonio& Lucherini, Orso Maria& Fabbiani, Alessandra& Capozio, Giovanna…[et al.]. 2019. Hints for Genetic and Clinical Differentiation of Adult-Onset Monogenic Autoinflammatory Diseases. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-29.
https://search.emarefa.net/detail/BIM-1192801
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gaggiano, Carla…[et al.]. Hints for Genetic and Clinical Differentiation of Adult-Onset Monogenic Autoinflammatory Diseases. Mediators of Inflammation No. 2019 (2019), pp.1-29.
https://search.emarefa.net/detail/BIM-1192801
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gaggiano, Carla& Rigante, Donato& Vitale, Antonio& Lucherini, Orso Maria& Fabbiani, Alessandra& Capozio, Giovanna…[et al.]. Hints for Genetic and Clinical Differentiation of Adult-Onset Monogenic Autoinflammatory Diseases. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-29.
https://search.emarefa.net/detail/BIM-1192801
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192801
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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