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Pharmacogenetic Biomarkers to Predict Treatment Response in Multiple Sclerosis: Current and Future Perspectives
المؤلف
المصدر
Multiple Sclerosis International
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Disease-modifying therapies (DMTs) have significantly advanced the treatment of relapsing multiple sclerosis (MS), decreasing the frequency of relapses, disability, and magnetic resonance imaging lesion formation.
However, patients’ responses to and tolerability of DMTs vary considerably, creating an unmet need for biomarkers to identify likely responders and/or those who may have treatment-limiting adverse reactions.
Most studies in MS have focused on the identification of pharmacogenetic markers, using either the candidate-gene approach, which requires prior knowledge of the genetic marker and its role in the target disease, or genome-wide association, which examines multiple genetic variants, typically single nucleotide polymorphisms (SNPs).
Both approaches have implicated numerous alleles and SNPs in response to selected MS DMTs.
None have been validated for use in clinical practice.
This review covers pharmacogenetic markers in clinical practice in other diseases and then reviews the current status of MS DMT markers (interferon β, glatiramer acetate, and mitoxantrone).
For a complex disease such as MS, multiple biomarkers may need to be evaluated simultaneously to identify potential responders.
Efforts to identify relevant biomarkers are underway and will need to be expanded to all MS DMTs.
These will require extensive validation in large patient groups before they can be used in clinical practice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Coyle, Patricia. 2017. Pharmacogenetic Biomarkers to Predict Treatment Response in Multiple Sclerosis: Current and Future Perspectives. Multiple Sclerosis International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1192847
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Coyle, Patricia. Pharmacogenetic Biomarkers to Predict Treatment Response in Multiple Sclerosis: Current and Future Perspectives. Multiple Sclerosis International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1192847
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Coyle, Patricia. Pharmacogenetic Biomarkers to Predict Treatment Response in Multiple Sclerosis: Current and Future Perspectives. Multiple Sclerosis International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1192847
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192847
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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