Following Spinal Cord Injury Transected Reticulospinal Tract Axons Develop New Collateral Inputs to Spinal Interneurons in Parallel with Locomotor Recovery
المؤلفون المشاركون
May, Zacnicte
Fenrich, Keith K.
Dahlby, Julia
Batty, Nicholas J.
Torres-Espín, Abel
Fouad, Karim
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-12
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The reticulospinal tract (RtST) descends from the reticular formation and terminates in the spinal cord.
The RtST drives the initiation of locomotion and postural control.
RtST axons form new contacts with propriospinal interneurons (PrINs) after incomplete spinal cord injury (SCI); however, it is unclear if injured or uninjured axons make these connections.
We completely transected all traced RtST axons in rats using a staggered model, where a hemisection SCI at vertebra T10 is followed by a contralateral hemisection at vertebra T7.
In one group of the animals, the T7 SCI was performed 2 weeks after the T10 SCI (delayed; dSTAG), and in another group, the T10 and T7 SCIs were concomitant (cSTAG).
dSTAG animals had significantly more RtST-PrIN contacts in the grey matter compared to cSTAG animals (p<0.05).
These results were accompanied by enhanced locomotor recovery with dSTAG animals significantly outperforming cSTAG animals (BBB test; p<0.05).
This difference suggests that activity in neuronal networks below the first SCI may contribute to enhanced recovery, because dSTAG rats recovered locomotor ability before the second hemisection.
In conclusion, our findings support the hypothesis that the injured RtST forms new connections and is a key player in the recovery of locomotion post-SCI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
May, Zacnicte& Fenrich, Keith K.& Dahlby, Julia& Batty, Nicholas J.& Torres-Espín, Abel& Fouad, Karim. 2017. Following Spinal Cord Injury Transected Reticulospinal Tract Axons Develop New Collateral Inputs to Spinal Interneurons in Parallel with Locomotor Recovery. Neural Plasticity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1192898
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
May, Zacnicte…[et al.]. Following Spinal Cord Injury Transected Reticulospinal Tract Axons Develop New Collateral Inputs to Spinal Interneurons in Parallel with Locomotor Recovery. Neural Plasticity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1192898
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
May, Zacnicte& Fenrich, Keith K.& Dahlby, Julia& Batty, Nicholas J.& Torres-Espín, Abel& Fouad, Karim. Following Spinal Cord Injury Transected Reticulospinal Tract Axons Develop New Collateral Inputs to Spinal Interneurons in Parallel with Locomotor Recovery. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1192898
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192898
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر