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Phenotypic Characterization of Circulating CD4+ T Cells in ANCA-Associated Vasculitis
المؤلفون المشاركون
Hellmark, Thomas
Lilliebladh, Sandra
Johansson, Åsa
Pettersson, Åsa
Ohlsson, Sophie
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
T cell-mediated immune responses are thought to play an important role in the pathogenesis of anti-neutrophil cytoplasmic antibody- (ANCA-) associated vasculitides (AAV).
CD4+ T cells can be divided into subsets depending on their expression of chemokine receptors.
In this study, different CD4+ T cell populations in patients with AAV were analysed and compared to healthy blood donors as well as therapy controls.
18 patients with active AAV, 46 in remission, 21 healthy controls (HBD), and 15 therapy controls (TC) were enrolled.
CD4+ T cells were divided into Th1, Th2, and Th17 cells and further subdivided into naïve, central memory, effector memory, and effector cells.
Regulatory T cells were also analysed.
Concentrations of cytokines and chemokines produced by the respective CD4+ T cell subset in plasma from 33 of the patients were measured by ELISA and compared to HBD.
Clinical data were collected on all patients.
CCL20 concentrations and percentages of Th17 cells (p=0.019) were elevated in AAV patients compared to HBD.
AAV patients had lower percentages of naïve CD4+ T cells (p=0.0016) and a corresponding increase in proportion of effector memory CD4+ T cells when comparing to HBD (p=0.027).
Therapy controls showed similar results as AAV patients.
In this study, we found that CD4+ T cell phenotype distribution is altered in AAV patients, in line with previously published work.
However, no differences were found between AAV patients and TC, stressing the importance of treatment impact on this kind of studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lilliebladh, Sandra& Johansson, Åsa& Pettersson, Åsa& Ohlsson, Sophie& Hellmark, Thomas. 2018. Phenotypic Characterization of Circulating CD4+ T Cells in ANCA-Associated Vasculitis. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1192904
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lilliebladh, Sandra…[et al.]. Phenotypic Characterization of Circulating CD4+ T Cells in ANCA-Associated Vasculitis. Journal of Immunology Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1192904
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lilliebladh, Sandra& Johansson, Åsa& Pettersson, Åsa& Ohlsson, Sophie& Hellmark, Thomas. Phenotypic Characterization of Circulating CD4+ T Cells in ANCA-Associated Vasculitis. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1192904
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192904
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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