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Role of Exercise in Vascular Function and Inflammatory Profile in Age-Related Obesity
المؤلفون المشاركون
Bacchi, Elisabetta
Pedrinolla, Anna
Venturelli, Massimo
Kirmizi, Emine
Moschetta, Federica
Zardini, Monica
Rudi, Doriana
Lanza, Massimo
Moghetti, Paolo
Schena, Federico
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
In western countries, aging is often accompanied by obesity and age-related obesity is characterized by vascular dysfunction and a low-grade inflammatory profile.
Exercise is a nonpharmacological strategy able to decrease the development and incidence of risk factors for several health-threatening diseases.
Nonetheless, its long-term effect on vascular function and inflammation in age-related obesity is still unclear.
The aim of this study was to investigate the effect of regular, supervised exercise on inflammatory profile and vascular function in age-related obesity.
We also hypothesized that vascular function and inflammatory profile would have been correlated in overweight and obese individuals.
Thirty normal weight (NW; 70 ± 5 years, 23.9 ± 2.6 BMI) and forty overweight and obese elderly (OW&OB; 69 ± 5 years, 30.1 ± 2.3 BMI) regularly taking part in a structured, supervised exercise program were enrolled in the study and evaluated for vascular function (flow-mediated dilation; FMD) and inflammatory profile (plasma CRP, IL-1β, IL-1ra, IL-6, IL-8, IL-10, TNF-α, and MCP-1).
Although no differences between groups were found concerning performance and the weekly amount of physical activity, the OW&OB group compared with the NW group demonstrated higher systolic and diastolic blood pressure (+10%, p=0.001; +9%, p=0.005, respectively); lower FMD% (−36%, p<0.001) and FMD/shear rate (−40%, p=0.001); and higher levels of CRP (+33%, p=0.005), IL-6 (+36%, p=0.048), MCP-1 (+17%, p=0.004), and TNF-α (+16%, p=0.031).
No correlations between vascular function and inflammation were found in OW&OB or NW.
Although exercising regularly, overweight and obese elderly exhibited poorer vascular function and higher proinflammatory markers compared with the leaner group.
These results support the idea that exercise alone cannot counteract the negative effect of adiposity on vascular function and inflammatory profile in elderly individuals and these two processes are not necessarily related.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pedrinolla, Anna& Venturelli, Massimo& Kirmizi, Emine& Moschetta, Federica& Zardini, Monica& Rudi, Doriana…[et al.]. 2018. Role of Exercise in Vascular Function and Inflammatory Profile in Age-Related Obesity. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1192916
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pedrinolla, Anna…[et al.]. Role of Exercise in Vascular Function and Inflammatory Profile in Age-Related Obesity. Journal of Immunology Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1192916
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pedrinolla, Anna& Venturelli, Massimo& Kirmizi, Emine& Moschetta, Federica& Zardini, Monica& Rudi, Doriana…[et al.]. Role of Exercise in Vascular Function and Inflammatory Profile in Age-Related Obesity. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1192916
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192916
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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