Mesenchymal Stem Cells Ameliorate Hepatic IschemiaReperfusion Injury via Inhibition of Neutrophil Recruitment
المؤلفون المشاركون
Liu, Wei
Li, Shihui
Zheng, Xu
Li, Hui
Zheng, Jun
Chen, Xiaolong
Tai, Yan
Zhang, Yingcai
Wang, Genshu
Yang, Yang
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Ischemia/reperfusion injury (IRI) remains a major problem in organ transplantation, which represents the main cause of graft dysfunction posttransplantation.
Hepatic IRI is characterized by an excessive inflammatory response within the liver.
Mesenchymal stem cells (MSCs) have been shown to be immunomodulatory cells and have the therapeutic action on IRI in several organs.
However, the mechanism of regulatory effect of MSCs on IRI remains unclear.
In the present study, we examined the impact of MSCs on hepatic inflammatory response such as neutrophil influx and liver damage in a rat model of 70% hepatic IRI.
Treatment with MSCs protected rat against hepatic IRI, with significantly decreased serum levels of liver enzymes, attenuated hepatic neutrophil infiltration, reduced expression of apoptosis-associated proteins, and ameliorated liver pathological injury.
MSCs also significantly enhanced the intracellular activation of p38 MAPK phosphorylation, which led to decreased expression of CXCR2 on the surface of neutrophils.
In addition, MSCs significantly diminished neutrophil chemoattractant CXCL2 production by inhibiting NF-κB p65 phosphorylation in macrophages.
These results demonstrate that MSCs significantly ameliorate hepatic IRI predominantly through its inhibitory effect on hepatic neutrophil migration and infiltration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Shihui& Zheng, Xu& Li, Hui& Zheng, Jun& Chen, Xiaolong& Liu, Wei…[et al.]. 2018. Mesenchymal Stem Cells Ameliorate Hepatic IschemiaReperfusion Injury via Inhibition of Neutrophil Recruitment. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192935
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Shihui…[et al.]. Mesenchymal Stem Cells Ameliorate Hepatic IschemiaReperfusion Injury via Inhibition of Neutrophil Recruitment. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192935
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Shihui& Zheng, Xu& Li, Hui& Zheng, Jun& Chen, Xiaolong& Liu, Wei…[et al.]. Mesenchymal Stem Cells Ameliorate Hepatic IschemiaReperfusion Injury via Inhibition of Neutrophil Recruitment. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192935
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192935
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر