Inhibition of CD83 Alleviates Systemic Inflammation in Herpes Simplex Virus Type 1-Induced Behçet’s Disease Model Mouse
المؤلفون المشاركون
Choi, Bunsoon
Sohn, Seonghyang
Islam, S. M. Shamsul
Byun, Hae-Ok
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-09
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Behçet’s disease (BD) is an autoinflammatory disease that can lead to life- and sight-threating complications.
Dendritic cells (DCs) are the most potent antigen-presenting cells that can regulate multiple inflammatory pathways.
The objective of this study was to investigate the association of the DC stimulatory molecule CD83 with BD.
Frequencies of costimulatory molecules expressing DCs in peripheral blood leukocytes (PBL) were measured by flow cytometry (FACS).
The severity of symptoms in HSV-1-induced BD symptomatic mice was also assessed.
Frequencies of CD83-positive cells were significantly increased in mice exhibiting BD symptoms, compared to those in asymptomatic mice.
Abatacept, a CD80/86 blocker, significantly decreased the frequencies of CD83-positive cells in a time- and dose-dependent manner.
BD symptomatic mice treated with Abatacept showed gradual reduction in the severity score of symptoms.
Intraperitoneal injection of CD83 siRNA significantly reduced the frequencies of CD83-positive cells in PBL and peritoneal macrophages.
After CD83 siRNA injection, BD symptoms of mice were improved and disease severity was decreased.
Discontinuation of CD83 siRNA deteriorated symptoms while readministration of CD83 siRNA again improved BD symptoms of mice.
These results clearly indicate the involvement of CD83-expressing cells in the inflammatory symptoms of BD.
Therefore, CD83 might be useful as a therapeutic target for BD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Islam, S. M. Shamsul& Byun, Hae-Ok& Choi, Bunsoon& Sohn, Seonghyang. 2019. Inhibition of CD83 Alleviates Systemic Inflammation in Herpes Simplex Virus Type 1-Induced Behçet’s Disease Model Mouse. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1192973
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Islam, S. M. Shamsul…[et al.]. Inhibition of CD83 Alleviates Systemic Inflammation in Herpes Simplex Virus Type 1-Induced Behçet’s Disease Model Mouse. Mediators of Inflammation No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1192973
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Islam, S. M. Shamsul& Byun, Hae-Ok& Choi, Bunsoon& Sohn, Seonghyang. Inhibition of CD83 Alleviates Systemic Inflammation in Herpes Simplex Virus Type 1-Induced Behçet’s Disease Model Mouse. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1192973
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192973
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر