Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the SpinophilinNeurofilament Medium Interaction
المؤلفون المشاركون
Hiday, Andrew C.
Edler, Michael C.
Salek, Asma B.
Morris, Cameron W.
Thang, Morrent
Rentz, Tyler J.
Rose, Kristie L.
Jones, Lisa M.
Baucum, Anthony J.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-28
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Signaling changes that occur in the striatum following the loss of dopamine neurons in the Parkinson disease (PD) are poorly understood.
While increases in the activity of kinases and decreases in the activity of phosphatases have been observed, the specific consequences of these changes are less well understood.
Phosphatases, such as protein phosphatase 1 (PP1), are highly promiscuous and obtain substrate selectivity via targeting proteins.
Spinophilin is the major PP1-targeting protein enriched in the postsynaptic density of striatal dendritic spines.
Spinophilin association with PP1 is increased concurrent with decreases in PP1 activity in an animal model of PD.
Using proteomic-based approaches, we observed dopamine depletion-induced decreases in spinophilin binding to multiple protein classes in the striatum.
Specifically, there was a decrease in the association of spinophilin with neurofilament medium (NF-M) in dopamine-depleted striatum.
Using a heterologous cell line, we determined that spinophilin binding to NF-M required overexpression of the catalytic subunit of protein kinase A and was decreased by cyclin-dependent protein kinase 5.
Functionally, we demonstrate that spinophilin can decrease NF-M phosphorylation.
Our data determine mechanisms that regulate, and putative consequences of, pathological changes in the association of spinophilin with NF-M that are observed in animal models of PD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hiday, Andrew C.& Edler, Michael C.& Salek, Asma B.& Morris, Cameron W.& Thang, Morrent& Rentz, Tyler J.…[et al.]. 2017. Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the SpinophilinNeurofilament Medium Interaction. Neural Plasticity،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1192999
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hiday, Andrew C.…[et al.]. Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the SpinophilinNeurofilament Medium Interaction. Neural Plasticity No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1192999
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hiday, Andrew C.& Edler, Michael C.& Salek, Asma B.& Morris, Cameron W.& Thang, Morrent& Rentz, Tyler J.…[et al.]. Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the SpinophilinNeurofilament Medium Interaction. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1192999
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192999
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر