The Polarization States of Microglia in TBI: A New Paradigm for Pharmacological Intervention
المؤلفون المشاركون
Wu, Haijian
Xu, Hangzhe
Wang, Zhijiang
Li, Jianru
Peng, Yucong
Fan, Linfeng
Chen, Jingyin
Gu, Chi
Yan, Feng
Wang, Lin
Chen, Gao
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-01
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Traumatic brain injury (TBI) is a serious medical and social problem worldwide.
Because of the complex pathophysiological mechanisms of TBI, effective pharmacotherapy is still lacking.
The microglial cells are resident tissue macrophages located in the brain and have two major polarization states, M1 phenotype and M2 phenotype, when activated.
The M1 phenotype is related to the release of proinflammatory cytokines and secondary brain injury, while the M2 phenotype has been proved to be responsible for the release of anti-inflammation cytokines and for central nervous system (CNS) repair.
In animal models, pharmacological strategies inhibiting the M1 phenotype and promoting the M2 phenotype of microglial cells could alleviate cerebral damage and improve neurological function recovery after TBI.
In this review, we aimed to summarize the current knowledge about the pathological significance of microglial M1/M2 polarization in the pathophysiology of TBI.
In addition, we reviewed several drugs that have provided neuroprotective effects against brain injury following TBI by altering the polarization states of the microglia.
We emphasized that future investigation of the regulation mechanisms of microglial M1/M2 polarization in TBI is anticipated, which could contribute to the development of new targets of pharmacological intervention in TBI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Hangzhe& Wang, Zhijiang& Li, Jianru& Wu, Haijian& Peng, Yucong& Fan, Linfeng…[et al.]. 2017. The Polarization States of Microglia in TBI: A New Paradigm for Pharmacological Intervention. Neural Plasticity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193051
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Hangzhe…[et al.]. The Polarization States of Microglia in TBI: A New Paradigm for Pharmacological Intervention. Neural Plasticity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1193051
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Hangzhe& Wang, Zhijiang& Li, Jianru& Wu, Haijian& Peng, Yucong& Fan, Linfeng…[et al.]. The Polarization States of Microglia in TBI: A New Paradigm for Pharmacological Intervention. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1193051
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193051
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر