Contribution of Statins towards Periodontal Treatment: A Review
المؤلفون المشاركون
Benkirane-Jessel, Nadia
Petit, Catherine
Batool, Fareeha
Bugueno, Isaac Maximiliano
Schwinté, Pascale
Huck, O.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-33، 33ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-27
دولة النشر
مصر
عدد الصفحات
33
التخصصات الرئيسية
الملخص EN
The pleiotropic effects of statins have been evaluated to assess their potential benefit in the treatment of various inflammatory and immune-mediated diseases including periodontitis.
Herein, the adjunctive use of statins in periodontal therapy in vitro, in vivo, and in clinical trials was reviewed.
Statins act through several pathways to modulate inflammation, immune response, bone metabolism, and bacterial clearance.
They control periodontal inflammation through inhibition of proinflammatory cytokines and promotion of anti-inflammatory and/or proresolution molecule release, mainly, through the ERK, MAPK, PI3-Akt, and NF-κB pathways.
Moreover, they are able to modulate the host response activated by bacterial challenge, to prevent inflammation-mediated bone resorption and to promote bone formation.
Furthermore, they reduce bacterial growth, disrupt bacterial membrane stability, and increase bacterial clearance, thus averting the exacerbation of infection.
Local statin delivery as adjunct to both nonsurgical and surgical periodontal therapies results in better periodontal treatment outcomes compared to systemic delivery.
Moreover, combination of statin therapy with other regenerative agents improves periodontal healing response.
Therefore, statins could be proposed as a potential adjuvant to periodontal therapy.
However, optimization of the combination of their dose, type, and carrier could be instrumental in achieving the best treatment response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Petit, Catherine& Batool, Fareeha& Bugueno, Isaac Maximiliano& Schwinté, Pascale& Benkirane-Jessel, Nadia& Huck, O.. 2019. Contribution of Statins towards Periodontal Treatment: A Review. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-33.
https://search.emarefa.net/detail/BIM-1193070
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Petit, Catherine…[et al.]. Contribution of Statins towards Periodontal Treatment: A Review. Mediators of Inflammation No. 2019 (2019), pp.1-33.
https://search.emarefa.net/detail/BIM-1193070
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Petit, Catherine& Batool, Fareeha& Bugueno, Isaac Maximiliano& Schwinté, Pascale& Benkirane-Jessel, Nadia& Huck, O.. Contribution of Statins towards Periodontal Treatment: A Review. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-33.
https://search.emarefa.net/detail/BIM-1193070
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193070
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر