Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation
المؤلفون المشاركون
Cunha, Fernando Queiroz
Cunha, Thiago Mattar
Casagrande, Rúbia
Verri, Waldiceu A.
Alves-Filho, José C.
Rossaneis, Ana C.
Bernardy, Catia C. F.
Domiciano, Talita P.
Lourenco-Gonzalez, Yuri
Fattori, Victor
Borghi, Sergio M.
Zaninelli, Tiago H.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-31
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Clinically active drugs for the treatment of acute pain have their prescription limited due to the significant side effects they induce.
An increase in reactive oxygen species (ROS) has been linked to several conditions, including inflammation and pain processing.
Therefore, new or repurposed drugs with the ability of reducing ROS-triggered responses are promising candidates for analgesic drugs.
Vinpocetine is a clinically used nootropic drug with antioxidant, anti-inflammatory, and analgesic properties.
However, the effects of vinpocetine have not been investigated in a model with a direct relationship between ROS, inflammation, and pain.
Based on that, we aimed to investigate the effects of vinpocetine in a model of superoxide anion-induced pain and inflammation using potassium superoxide (KO2) as a superoxide anion donor to trigger inflammation and pain.
In the KO2 model, vinpocetine dose-dependently reduced pain-like behaviors (spontaneous pain and hyperalgesia), paw edema, and neutrophil and mononuclear cell recruitment to the paw skin (assessed by H&E staining, fluorescence, and enzymatic assays) and to the peritoneal cavity.
Vinpocetine also restored tissue endogenous antioxidant ability and Nrf2 and Ho-1 mRNA expression and reduced superoxide anion production and gp91phox mRNA expression.
We also observed the inhibition of IκBα degradation by vinpocetine, which demonstrates a reduction in the activation of NF-κB explaining the diminished production of IL-33, IL-1β, and TNF-α.
Collectively, our data show that vinpocetine alleviates pain and inflammation induced by KO2, which is a mouse model with a direct role of ROS in triggering pain and other inflammatory phenomena.
Thus, the results suggest the repurposing of vinpocetine as an anti-inflammatory and analgesic drug.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lourenco-Gonzalez, Yuri& Fattori, Victor& Domiciano, Talita P.& Rossaneis, Ana C.& Borghi, Sergio M.& Zaninelli, Tiago H.…[et al.]. 2019. Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1193093
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lourenco-Gonzalez, Yuri…[et al.]. Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation. Mediators of Inflammation No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1193093
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lourenco-Gonzalez, Yuri& Fattori, Victor& Domiciano, Talita P.& Rossaneis, Ana C.& Borghi, Sergio M.& Zaninelli, Tiago H.…[et al.]. Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1193093
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193093
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر