Role of Regulatory B Cells in the Progression of Cervical Cancer

المؤلفون المشاركون

Ding, Jianbing
Pang, Nannan
Zhang, Fengbo
Chen, Zhifang
Du, Rong
Zhu, Yuejie
Ding, Yan
Dong, Di

المصدر

Mediators of Inflammation

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-06-18

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض

الملخص EN

This study is to investigate the role of regulatory B (Breg) cells in cervical cancer.

In total, 70 cases of cervical cancer, 52 cases of cervical intraepithelial neoplasia (CIN), and 40 normal controls were enrolled.

The percentage of Breg cells was detected by flow cytometry.

Serum levels of IL-10 were measured by ELISA.

The correlation between Breg cells and the clinical characterizations of cervical cancer was analyzed.

The inhibition effect of Breg cells on CD8+ T cells was tested by blocking IL-10 in vitro.

The percentage of CD19+CD5+CD1d+ Breg cells and the level of IL-10 of patients with cervical cancer or CIN were significantly higher than those in the control group (P<0.05).

And the postoperative levels of Breg cells and IL-10 were significantly lower than the preoperative levels (P<0.05).

Breg cells and the IL-10 level were positively correlated in cervical cancer patients (r=0.516).

In addition, the Breg cell percentage was closely related to the FIGO stages, lymph node metastasis, tumor differentiation, HPV infection, and the tumor metastasis of cervical cancer (P<0.05).

The Breg cell percentage was negatively correlated with CD8+ T cells of cervical cancer patients (r=‐0.669).

The level of IL-10 in the culture supernatant of Bregs treated with CpG was significantly higher than that of non-Bregs (P<0.05).

After coculture with Bregs, the quantity of CD8+ T cells to secrete perforin and Granzyme B was significantly decreased, and this effect was reversed after blocking IL-10 by a specific antibody.

Breg cells are elevated in cervical cancer and associated with disease progression and metastasis.

Moreover, they can inhibit the cytotoxicity of CD8+ T cells.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Chen, Zhifang& Zhu, Yuejie& Du, Rong& Pang, Nannan& Zhang, Fengbo& Dong, Di…[et al.]. 2019. Role of Regulatory B Cells in the Progression of Cervical Cancer. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1193101

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Chen, Zhifang…[et al.]. Role of Regulatory B Cells in the Progression of Cervical Cancer. Mediators of Inflammation No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1193101

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Chen, Zhifang& Zhu, Yuejie& Du, Rong& Pang, Nannan& Zhang, Fengbo& Dong, Di…[et al.]. Role of Regulatory B Cells in the Progression of Cervical Cancer. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1193101

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1193101