miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years
المؤلفون المشاركون
Koch, Alexander
Benz, Fabian
Roderburg, Christoph
Luedde, Mark
Vucur, Mihael
Hippe, Hans-Joerg
Spehlmann, Martina E.
Loosen, Sven
Frey, Norbert
Roy, Sanchari
Cardenas, David Vargas
Luedde, Tom
Trautwein, Christian
Tacke, Frank
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
Alterations in miR-155 serum levels have been described in inflammatory and infectious diseases.
Moreover, a role for miR-155 in aging and age-related diseases was recently suggested.
We therefore analyzed a potential age-dependent prognostic value of circulating miR-155 as a serum-based marker in critical illness.
Methods.
Concentrations of circulating miR-155 were determined in 218 critically ill patients and 76 healthy controls.
Results.
By using qPCR, we demonstrate that miR-155 serum levels are elevated in patients with critical illness when compared to controls.
Notably, levels of circulating miR-155 were independent on the severity of disease, the disease etiology, or the presence of sepsis.
In the total cohort, miR-155 was not an indicator for patient survival.
Intriguingly, when patients were subdivided according to their age upon admission to the ICU into those younger than 65 years, lower levels of miR-155 turned out as a strong marker, indicating patient mortality with a similar accuracy than other markers frequently used to evaluate critically ill patients on a medical ICU.
Conclusion.
In summary, the data provided within this study suggest an age-specific role of miR-155 as a prognostic biomarker in patients younger than 65 years.
Our study is the first to describe an age-dependent miRNA-based prognostic biomarker in human diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tacke, Frank& Spehlmann, Martina E.& Vucur, Mihael& Benz, Fabian& Luedde, Mark& Cardenas, David Vargas…[et al.]. 2019. miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1193141
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tacke, Frank…[et al.]. miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years. Mediators of Inflammation No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1193141
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tacke, Frank& Spehlmann, Martina E.& Vucur, Mihael& Benz, Fabian& Luedde, Mark& Cardenas, David Vargas…[et al.]. miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1193141
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193141
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر