Relationship between Helicobacter pylori Infection and Plasmacytoid and Myeloid Dendritic Cells in Peripheral Blood and Gastric Mucosa of Children
المؤلفون المشاركون
Helmin-Basa, Anna
Gackowska, Lidia
Bodnar, Magdalena
Wiese, Małgorzata
Marszalek, Andrzej
Januszewska, Milena
Szaflarska-Poplawska, Anna
Kłosowski, Maciej
Michalkiewicz, Jacek
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-11
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Purpose.
To investigate the frequency and activation status of peripheral plasmacytoid DCs (pDCs) and myeloid DCs (mDCs) as well as gastric mucosa DC subset distribution in Helicobacter pylori- (H.
pylori-) infected and noninfected children.
Materials and Methods.
Thirty-six children were studied; twenty-one had H.
pylori.
The frequencies of circulating pDCs (lineage-HLA-DR+CD123+) and mDCs (lineage-HLA-DR+CD11c+) and their activation status (CD83, CD86, and HLA-DR expression) were assessed by flow cytometry.
Additionally, the densities of CD11c+, CD123+, CD83+, CD86+, and LAMP3+ cells in the gastric mucosa were determined by immunohistochemistry.
Results.
The frequency of circulating CD83+ mDCs was higher in H.
pylori-infected children than in the noninfected controls.
The pDCs demonstrated upregulated HLA-DR surface expression, but no change in CD86 expression.
Additionally, the densities of gastric lamina propria CD11c+ cells and epithelial pDCs were increased.
There was a significant association between frequency of circulating CD83+ mDCs and gastric lamina propria mDC infiltration.
Conclusion.
This study shows that although H.
pylori-infected children had an increased population of mature mDCs bearing CD83 in the peripheral blood, they lack mature CD83+ mDCs in the gastric mucosa, which may promote tolerance to local antigens rather than immunity.
In addition, this may reduce excessive inflammatory activity as reported for children compared to adults.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Helmin-Basa, Anna& Wiese, Małgorzata& Szaflarska-Poplawska, Anna& Kłosowski, Maciej& Januszewska, Milena& Bodnar, Magdalena…[et al.]. 2019. Relationship between Helicobacter pylori Infection and Plasmacytoid and Myeloid Dendritic Cells in Peripheral Blood and Gastric Mucosa of Children. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1193220
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Helmin-Basa, Anna…[et al.]. Relationship between Helicobacter pylori Infection and Plasmacytoid and Myeloid Dendritic Cells in Peripheral Blood and Gastric Mucosa of Children. Mediators of Inflammation No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1193220
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Helmin-Basa, Anna& Wiese, Małgorzata& Szaflarska-Poplawska, Anna& Kłosowski, Maciej& Januszewska, Milena& Bodnar, Magdalena…[et al.]. Relationship between Helicobacter pylori Infection and Plasmacytoid and Myeloid Dendritic Cells in Peripheral Blood and Gastric Mucosa of Children. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1193220
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193220
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر