Acupuncture Attenuates Renal Sympathetic Activity and Blood Pressure via Beta-Adrenergic Receptors in Spontaneously Hypertensive Rats
المؤلفون المشاركون
Liu, Cun-Zhi
Yang, Jing-Wen
Li, Fang
Xiao, Ling-Yong
Wang, Xue-Rui
Ye, Yang
Shi, Guang-Xia
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The sympathetic nervous system, via epinephrine and norepinephrine, regulates β-adrenergic receptor (β-AR) expression, and renal sympathetic activation causes sustained increases in blood pressure by enhanced renin release.
In this study, we aim to investigate the effect and underlying mechanism of acupuncture at Taichong (LR3) on renal sympathetic activity in spontaneously hypertensive rats.
Unanesthetized rats were subject to daily acupuncture for 2 weeks.
Mean blood pressure (MBP) and heart rate variability (HRV) were monitored at days 0, 7, and 14 by radiotelemetry.
After euthanasia on the 14th day, blood and the kidneys were collected and subject to the following analyses.
Epinephrine and norepinephrine were detected by ELISA.
The expression of β-ARs was studied by western blotting and PCR.
The renin content was analyzed by radioimmunoassay.
14-day acupuncture significantly attenuates the increase of MBP.
The HRV indices, the standard deviation of all normal NN intervals (SDNN), and the ratio of the low-frequency component to the high-frequency component (LF/HF) were improved following acupuncture.
Renal sympathetic activation induced upregulation of epinephrine, norepinephrine, and renin content were attenuated by acupuncture.
In addition, acupuncture decreased β1-AR expression and improved β2-AR expression.
These results indicated that acupuncture relieves the increased MBP via the regulation of renal sympathetic activity and β-ARs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Jing-Wen& Ye, Yang& Wang, Xue-Rui& Li, Fang& Xiao, Ling-Yong& Shi, Guang-Xia…[et al.]. 2017. Acupuncture Attenuates Renal Sympathetic Activity and Blood Pressure via Beta-Adrenergic Receptors in Spontaneously Hypertensive Rats. Neural Plasticity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1193277
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Jing-Wen…[et al.]. Acupuncture Attenuates Renal Sympathetic Activity and Blood Pressure via Beta-Adrenergic Receptors in Spontaneously Hypertensive Rats. Neural Plasticity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1193277
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Jing-Wen& Ye, Yang& Wang, Xue-Rui& Li, Fang& Xiao, Ling-Yong& Shi, Guang-Xia…[et al.]. Acupuncture Attenuates Renal Sympathetic Activity and Blood Pressure via Beta-Adrenergic Receptors in Spontaneously Hypertensive Rats. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1193277
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193277
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر