Matrix Metalloproteinase-9-Dependent Release of IL-1β by Human Eosinophils
المؤلفون المشاركون
Esnault, Stephane
Kelly, Elizabeth A.
Johnson, Sean H.
DeLain, Larissa P.
Haedt, Madeline J.
Noll, Andrea L.
Sandbo, Nathan
Jarjour, Nizar N.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Asthma is often associated with airway eosinophilia, and therapies targeting eosinophils are now available to treat severe eosinophilic asthma.
Eosinophilic asthma is often due to a type-2 immune response and production of IL-5, which leads to eosinophilopiesis and recruitment of mature eosinophils in the airways.
A concomitant type-2 and type-17 response has been reported in some individuals.
IL-17 may be enhanced by IL-1β production and can lead to neutrophilic inflammation.
In fact, both eosinophilic and neutrophilic (mixed granulocytic) inflammation are simultaneously present in a large population of patients with asthma.
In monocyte/macrophage cell populations, release of mature IL-1β occurs via toll-like receptor ligand-induced activation of the inflammasome.
Within the inflammasome, a cascade of events leads to the activation of caspase-1, which cleaves pro-IL-1β protein into a mature, releasable, and active form.
We have demonstrated that eosinophils can release IL-1β in a Toll-like receptor ligand-independent fashion.
The objective of this study was to determine the mechanisms underlying the production and maturation of IL-1β in cytokine-activated eosinophils.
Using eosinophils from circulating blood and from bronchoalveolar lavage fluid after an airway allergen challenge, the present study demonstrates that cytokine-activated eosinophils express and release a bioactive form of IL-1β with an apparent size less than the typical 17 kDa mature form produced by macrophages.
Using a zymography approach and pharmacological inhibitors, we identified matrix metalloproteinase-9 (MMP-9) as a protease that cleaves pro-IL-1β into a ~15 kDa form and allows the release of IL-1β from cytokine-activated eosinophils.
Therefore, we conclude that activated eosinophils produce MMP-9, which causes the release of IL-1β in an inflammasome/caspase-1-independent manner.
The production of IL-1β by eosinophils may be a link between the eosinophilic/type-2 immune response and the neutrophilic/type-17 immune response that is often associated with a more severe and treatment-refractory type of asthma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Esnault, Stephane& Kelly, Elizabeth A.& Johnson, Sean H.& DeLain, Larissa P.& Haedt, Madeline J.& Noll, Andrea L.…[et al.]. 2019. Matrix Metalloproteinase-9-Dependent Release of IL-1β by Human Eosinophils. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1193281
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Esnault, Stephane…[et al.]. Matrix Metalloproteinase-9-Dependent Release of IL-1β by Human Eosinophils. Mediators of Inflammation No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1193281
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Esnault, Stephane& Kelly, Elizabeth A.& Johnson, Sean H.& DeLain, Larissa P.& Haedt, Madeline J.& Noll, Andrea L.…[et al.]. Matrix Metalloproteinase-9-Dependent Release of IL-1β by Human Eosinophils. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1193281
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193281
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر