A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune Disease
المؤلفون المشاركون
McEvoy, Mark
Attia, John
Iseme, Rosebella A.
Kelly, Brian
Agnew, Linda
Walker, Frederick R.
Boyle, Michael
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-30
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Bone loss is characteristic of the ageing process and a common complication of many autoimmune diseases.
Research has highlighted a potential role of autoantibodies in pathologic bone loss.
The confounding effects of immunomodulatory drugs make it difficult to establish the contribution of autoantibodies amongst autoimmune disease sufferers.
We attempted to examine the relationship between autoantibodies and bone mass in a population of 2812 elderly participants without clinical autoimmune disease.
Serum samples were assayed for a panel of autoantibodies (anti-nuclear, extractable nuclear antigen, anti-neutrophil cytoplasmic, thyroid peroxidase, tissue transglutaminase, anti-cardiolipin, rheumatoid factor, and cyclic citrullinated peptide).
Bone mass was measured using quantitative ultrasound (QUS) of the calcaneus.
The relationship between each autoantibody and bone mass was determined using linear regression models.
Anti-nuclear autoantibodies were the most prevalent, positive in approximately 11%, and borderline in roughly 23% of our sample.
They were also the only autoantibody observed to be significantly associated with QUS index in the univariate analysis (n=1628; r=−0.20; 95% CI: −0.40–0.00; p=0.046).
However, statistical significance was lost after adjustment for various other potential confounders.
None of the other autoantibodies was associated with QUS index in either univariate or multivariate analysis.
We are limited by the cross-sectional nature of the study and the low prevalence of autoantibodies in our nonclinical sample.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Iseme, Rosebella A.& McEvoy, Mark& Kelly, Brian& Agnew, Linda& Walker, Frederick R.& Boyle, Michael…[et al.]. 2018. A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune Disease. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1193295
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Iseme, Rosebella A.…[et al.]. A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune Disease. Journal of Immunology Research No. 2018 (2018), pp.1-19.
https://search.emarefa.net/detail/BIM-1193295
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Iseme, Rosebella A.& McEvoy, Mark& Kelly, Brian& Agnew, Linda& Walker, Frederick R.& Boyle, Michael…[et al.]. A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune Disease. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1193295
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193295
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر