Effects of SHINBARO2 on Rat Models of Lumbar Spinal Stenosis
المؤلفون المشاركون
Ha, In-Hyuk
Lee, Sang Kook
Lee, Jinho
Shin, Joon-Shik
Park, So Hyun
Hong, Ji-Young
Kim, Won Kyung
Chung, Hwa-Jin
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Lumbar spinal stenosis (LSS) is a major cause of chronic low back pain; however, only a few therapies which have been used in clinics still have limited effects on functional recovery.
SHINBARO2 is a refined traditional formulation for inflamed lesions and relieve pain of muscular skeletal disease.
This study aimed at investigating the effects of SHINBARO2 on LSS and at determining its underlying molecular mechanism in rat models.
The LSS rat models were set up by surgical operations in 6-week-old male Sprague-Dawley rats.
SHINBARO2 was orally or intraperitoneally administered for 14 days.
The motor and sensory ability of rats were evaluated using the activity cage and hot plate method.
On the termination day, total vertebrae including the disc and spinal cord were excised for ex vivo study.
SHINBARO2 improved locomotor functions and pain sensitivity in LSS rat models.
Mechanism study suggested that SHINBARO2 inhibited the production of nitric oxide and prostaglandin E2 in tissues from LSS-induced rats.
SHINBARO2 also suppressed the expression of proinflammatory cytokines including tumor necrosis factor-α and interleukin-1β.
The activation of NF-κB by LSS surgery was effectively reduced by SHINBARO2, which coincided with the inhibition of IκB degradation.
In addition, brain-derived neurotrophic factor (BDNF), a potent promoter of neurite growth, and its downstream ERK signaling were also regulated by SHINBARO2.
These findings suggest that the effect of SHINBARO2 might be associated in part with the anti-inflammation and pain control in LSS rat models.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, So Hyun& Hong, Ji-Young& Kim, Won Kyung& Shin, Joon-Shik& Lee, Jinho& Ha, In-Hyuk…[et al.]. 2019. Effects of SHINBARO2 on Rat Models of Lumbar Spinal Stenosis. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1193304
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, So Hyun…[et al.]. Effects of SHINBARO2 on Rat Models of Lumbar Spinal Stenosis. Mediators of Inflammation No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1193304
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, So Hyun& Hong, Ji-Young& Kim, Won Kyung& Shin, Joon-Shik& Lee, Jinho& Ha, In-Hyuk…[et al.]. Effects of SHINBARO2 on Rat Models of Lumbar Spinal Stenosis. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1193304
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193304
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر