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Clinical Significance of Serum Galectin-9 and Soluble CD155 Levels in Patients with Systemic Sclerosis
المؤلفون المشاركون
Yanaba, Koichi
Asahina, Akihiko
Chihara, Mami
Kurita, Miki
Yoshihara, Yuki
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-27
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Signaling through coinhibitory receptors downregulates the immune response to prevent excessive immune activation and maintain optimal immunity and tolerance.
The aim of this study was to examine the levels of the soluble forms of coinhibitory receptors and their ligands, namely, galectin-9 (the ligand of T-cell immunoglobulin and mucin domain 3) and CD155 (the ligand of T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain), and their association with clinical features in patients with systemic sclerosis (SSc).
The serum levels of galectin-9 and soluble sCD155 were examined by enzyme-linked immunosorbent assays in patients with SSc, and the results were evaluated with respect to clinical features.
Patients with SSc exhibited raised serum levels of galectin-9, but not sCD155.
Serum galectin-9 levels were raised not only in patients with diffuse cutaneous SSc but also in patients with limited cutaneous SSc.
Furthermore, serum galectin-9 levels correlated positively with the erythrocyte sedimentation rate.
In addition, increased serum galectin-9 levels tended to be associated with higher mortality and serious organ involvement.
These results suggest that galectin-9, but not CD155, may be involved in the pathogenesis of SSc.
In addition, the measurement of serum galectin-9 levels could be used to predict serious organ involvement and high mortality in patients with SSc.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chihara, Mami& Kurita, Miki& Yoshihara, Yuki& Asahina, Akihiko& Yanaba, Koichi. 2018. Clinical Significance of Serum Galectin-9 and Soluble CD155 Levels in Patients with Systemic Sclerosis. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1193307
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chihara, Mami…[et al.]. Clinical Significance of Serum Galectin-9 and Soluble CD155 Levels in Patients with Systemic Sclerosis. Journal of Immunology Research No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1193307
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chihara, Mami& Kurita, Miki& Yoshihara, Yuki& Asahina, Akihiko& Yanaba, Koichi. Clinical Significance of Serum Galectin-9 and Soluble CD155 Levels in Patients with Systemic Sclerosis. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1193307
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193307
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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