On-the-Scene Hyaluronan and Syndecan-1 Serum Concentrations and Outcome after Cardiac Arrest and Resuscitation

المؤلفون المشاركون

Kusmenkov, T.
Ney, L.
Bogner, V.
Braunstein, Mareen
Böcker, Wolfgang
Ocker, L. E.
Tschoep, J.
Annecke, T.

المصدر

Mediators of Inflammation

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-04-17

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض

الملخص EN

Background.

It is not predictable which patients will develop a severe inflammatory response after successful cardiopulmonary resuscitation (CPR), also known as “postcardiac arrest syndrome.” This pathology affects only a subgroup of cardiac arrest victims.

Whole body ischemia/reperfusion and prolonged shock states after return of spontaneous circulation (ROSC) may both contribute to this devastating condition.

The vascular endothelium with its glycocalyx is especially susceptible to initial ischemic damage and may play a detrimental role in the initiation of postischemic inflammatory reactions.

It is not known to date if an immediate early damage to the endothelial glycocalyx, detected by on-the-scene blood sampling and measurement of soluble components (hyaluronan and syndecan-1), precedes and predicts multiple organ failure (MOF) and survival after ROSC.

Methods.

15 patients after prehospital resuscitation were included in the study.

Serum samples were collected on the scene immediately after ROSC and after 6 h, 12 h, 24 h, and 48 h.

Hyaluronan and syndecan-1 were measured by ELISA.

We associated the development of multiple organ failure and 30-day survival rates with these serum markers of early glycocalyx damage.

Results.

Immediate serum hyaluronan concentrations show significant differences depending on 30-day survival.

Further, the hyaluronan level is significantly higher in patients developing MOF during the initial and intermediate resuscitation period.

Also, the syndecan-1 levels are significantly different according to MOF occurrence.

Conclusion.

Serum markers of glycocalyx shedding taken immediately on the scene after ROSC can predict the occurrence of multiple organ failure and adverse clinical outcome in patients after cardiac arrest.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Bogner, V.& Braunstein, Mareen& Ocker, L. E.& Kusmenkov, T.& Tschoep, J.& Ney, L.…[et al.]. 2019. On-the-Scene Hyaluronan and Syndecan-1 Serum Concentrations and Outcome after Cardiac Arrest and Resuscitation. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1193375

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Bogner, V.…[et al.]. On-the-Scene Hyaluronan and Syndecan-1 Serum Concentrations and Outcome after Cardiac Arrest and Resuscitation. Mediators of Inflammation No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1193375

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Bogner, V.& Braunstein, Mareen& Ocker, L. E.& Kusmenkov, T.& Tschoep, J.& Ney, L.…[et al.]. On-the-Scene Hyaluronan and Syndecan-1 Serum Concentrations and Outcome after Cardiac Arrest and Resuscitation. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1193375

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1193375