Vagotomy Reduces Insulin Clearance in Obese Mice Programmed by Low-Protein Diet in the Adolescence
المؤلفون المشاركون
Costa-Júnior, José M.
Vettorazzi, Jean F.
Carneiro, Everardo M.
Boschero, Antonio C.
Lubaczeuski, Camila
Gonçalves, Luciana Mateus
Kurauti, Mirian Ayumi
Santos-Silva, Junia Carolina
Bonfleur, Maria Lúcia
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The aim of this study was to investigate the effect of subdiaphragmatic vagotomy on insulin sensitivity, secretion, and degradation in metabolic programmed mice, induced by a low-protein diet early in life, followed by exposure to a high-fat diet in adulthood.
Weaned 30-day-old C57Bl/6 mice were submitted to a low-protein diet (6% protein).
After 4 weeks, the mice were distributed into three groups: LP group, which continued receiving a low-protein diet; LP + HF group, which started to receive a high-fat diet; and LP + HFvag group, which underwent vagotomy and also was kept at a high-fat diet.
Glucose-stimulated insulin secretion (GSIS) in isolated islets, ipGTT, ipITT, in vivo insulin clearance, and liver expression of the insulin-degrading enzyme (IDE) was accessed.
Vagotomy improved glucose tolerance and reduced insulin secretion but did not alter adiposity and insulin sensitivity in the LP + HFvag, compared with the LP + HF group.
Improvement in glucose tolerance was accompanied by increased insulinemia, probably due to a diminished insulin clearance, as judged by the lower C-peptide : insulin ratio, during the ipGTT.
Finally, vagotomy also reduced liver IDE expression in this group.
In conclusion, when submitted to vagotomy, the metabolic programmed mice showed improved glucose tolerance, associated with an increase of plasma insulin concentration as a result of insulin clearance reduction, a phenomenon probably due to diminished liver IDE expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lubaczeuski, Camila& Gonçalves, Luciana Mateus& Vettorazzi, Jean F.& Kurauti, Mirian Ayumi& Santos-Silva, Junia Carolina& Bonfleur, Maria Lúcia…[et al.]. 2017. Vagotomy Reduces Insulin Clearance in Obese Mice Programmed by Low-Protein Diet in the Adolescence. Neural Plasticity،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1193384
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lubaczeuski, Camila…[et al.]. Vagotomy Reduces Insulin Clearance in Obese Mice Programmed by Low-Protein Diet in the Adolescence. Neural Plasticity No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1193384
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lubaczeuski, Camila& Gonçalves, Luciana Mateus& Vettorazzi, Jean F.& Kurauti, Mirian Ayumi& Santos-Silva, Junia Carolina& Bonfleur, Maria Lúcia…[et al.]. Vagotomy Reduces Insulin Clearance in Obese Mice Programmed by Low-Protein Diet in the Adolescence. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1193384
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193384
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر