Accumulation of α-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers
المؤلفون المشاركون
Taskiran, Dilek
Erbaş, Oytun
Aktuğ, Hüseyin
Solmaz, Volkan
Köse Özlece, Hatice
Eroglu, Hüseyin Avni
المصدر
Neurology Research International
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-04
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
The present study was conducted to evaluate the relationship between plasma oxidative stress markers such as malondialdehyde (MDA) and glutathione (GSH), inflammatory marker pentraxin-3 (PTX3), and cerebellar accumulation of α-synuclein in streptozotocin- (STZ-) induced diabetes model in rats.
Methods.
Twelve rats were included in the study.
Diabetes (n=6) was induced with a single intraperitoneal injection of streptozotocin (STZ, 60 mg/kg).
Diabetes was verified after 48 h by measuring blood glucose levels.
Six rats served as controls.
Following 8 weeks, rats were sacrificed for biochemical and immunohistochemical evaluation.
Results.
Plasma MDA levels were significantly higher in diabetic rats when compared with the control rats (p<0.01), while plasma GSH levels were lower in the diabetic group than in the control group (p<0.01).
Also, plasma pentraxin-3 levels were statistically higher in diabetic rats than in the control rats (p<0.01).
The analysis of cerebellar α-synuclein immunohistochemistry showed a significant increase in α-synuclein immunoexpression in the diabetic group compared to the control group (p<0.01).
Conclusion.
Due to increased inflammation and oxidative stress in the chronic period of hyperglycemia linked to diabetes, there may be α-synuclein accumulation in the cerebellum and the plasma PTX3 levels may be assessed as an important biomarker of this situation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Solmaz, Volkan& Köse Özlece, Hatice& Eroglu, Hüseyin Avni& Aktuğ, Hüseyin& Erbaş, Oytun& Taskiran, Dilek. 2017. Accumulation of α-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers. Neurology Research International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1193414
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Solmaz, Volkan…[et al.]. Accumulation of α-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers. Neurology Research International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1193414
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Solmaz, Volkan& Köse Özlece, Hatice& Eroglu, Hüseyin Avni& Aktuğ, Hüseyin& Erbaş, Oytun& Taskiran, Dilek. Accumulation of α-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers. Neurology Research International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1193414
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193414
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر